SynthesisNeuroradiology2020
Early computed tomography for acute post-traumatic diffuse axonal injury: a systematic review.
Synthesis in Neuroradiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 25 citations in OpenAlex.
- Surgical timing and mortality in acute traumatic subdural hematoma: is the four-hour threshold confounded by injury severity?European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026Article
- Advances in research on biomaterials and stem cell/exosome-based strategies in the treatment of traumatic brain injury.Acta pharmaceutica Sinica. B · 2025Review
- Progranulin Plays a Protective Role in Pneumococcal Meningitis by Inhibiting Pyroptosis.Immunity, inflammation and disease · 2025Article
- The Relationship between Injury Characteristics and Post-Traumatic Recovery after Diffuse Axonal Injury.Biomedicines · 2024Article
- Prehospital Electroencephalography to Detect Traumatic Brain Injury during Helicopter Transport: A Pilot Observational Cohort Study.Prehospital emergency care · 2024Review
- The Role of Novel Imaging and Biofluid Biomarkers in Traumatic Axonal Injury: An Updated Review.Biomedicines · 2023Review
- Prediction of Intracranial Infection in Patients under External Ventricular Drainage and Neurological Intensive Care: A Multicenter Retrospective Cohort Study.Journal of clinical medicine · 2022Article
- Complex Pathophysiology of Abusive Head Trauma with Poor Neurological Outcome in Infants.Journal of Korean Neurosurgical Society · 2022Article
- The ratio of serum neuron-specific enolase level to admission glasgow coma scale score is associated with diffuse axonal injury in patients with moderate to severe traumatic brain injury.Frontiers in neurology · 2022Article
- Serial assessment of the novel biomarker MFGE8 in comparison with GFAP for predicting severity and outcome after traumatic brain injury.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeDiffuse axonal injury (DAI) is the rupture of multiple axons due to acceleration and deceleration forces during a closed head injury. Most traumatic brain injuries (TBI) have some degree of DAI, especially severe TBI. Computed tomography (CT) remains the first imaging test performed in the acute phase of TBI, but has low sensitivity for detecting DAI, since DAI is a cellular lesion. The aim of this study is to search in the literature for CT signs, in the first 24 h after TBI, that may help to differentiate patients in groups with a better versus worst prognosis.
methodsWe searched for primary scientific articles in the PubMed database, in English, indexed since January 1st, 2000.
resultsFive articles were selected for review. In the DAI group, traffic accidents accounted 70% of the cases, 79% were male, and the mean age was 41 years. There was an association between DAI and intraventricular hemorrhage (IVH) and traumatic subarachnoid hemorrhage (tSAH); an association between the IVH grade and number of corpus callosum lesions; and an association between blood in the interpeduncular cisterns (IPC) and brainstem lesions.
conclusionIn closed TBI with no tSAH, severe DAI is unlikely. Similarly, in the absence of IVH, any DAI is unlikely. If there is IVH, patients generally are clinically worse; and the more ventricles affected, the worse the prognosis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.