ArticlePLoS neglected tropical diseases2020
Accounting for population structure reveals ambiguity in the Zaire Ebolavirus reservoir dynamics.
Article in PLoS neglected tropical diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Phylogenetic analysis of the 2025 Ebola outbreak in the Democratic Republic of the Congo.Nature communications · 2026Article
- Investigating the spatiotemporal links between the EVD outbreaks in Likati (2017) and Eastern DRC (2018-2020): a retrospective transdisciplinary study.BMC infectious diseases · 2026Article
- Recurrent Ebola outbreaks in the eastern Democratic Republic of the Congo: A wake-up call to scale up the integrated disease surveillance and response strategy.One health (Amsterdam, Netherlands) · 2022Article
- Comparing infectivity and virulence of emerging SARS-CoV-2 variants in Syrian hamsters.EBioMedicine · 2021Article
- STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters.Nature communications · 2020Article
- Genomic epidemiology and evolutionary dynamics of respiratory syncytial virus group B in Kilifi, Kenya, 2015-17.Virus evolution · 2020Article
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14 authors.
Funding
Abstract
Ebolaviruses pose a substantial threat to wildlife populations and to public health in Africa. Evolutionary analyses of virus genome sequences can contribute significantly to elucidate the origin of new outbreaks, which can help guide surveillance efforts. The reconstructed between-outbreak evolutionary history of Zaire ebolavirus so far has been highly consistent. By removing the confounding impact of population growth bursts during local outbreaks on the free mixing assumption that underlies coalescent-based demographic reconstructions, we find-contrary to what previous results indicated-that the circulation dynamics of Ebola virus in its animal reservoir are highly uncertain. Our findings also accentuate the need for a more fine-grained picture of the Ebola virus diversity in its reservoir to reliably infer the reservoir origin of outbreak lineages. In addition, the recent appearance of slower-evolving variants is in line with latency as a survival mechanism and with bats as the natural reservoir host.
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