Evidence map›Paper›PMID 32130024›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2020

Chemical sympathectomy reduces peripheral inflammatory responses to acute and chronic sleep fragmentation.

Ila Mishra, Keelee B Pullum, Domnique C Thayer, Erica R Plummer, Benjamin W Conkright, Andrew J Morris, Bruce F O'Hara, Gregory E Demas, Noah T Ashley

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Cornelian Cherry (Biology · 2025
    Article
  9. Sleep advances : a journal of the Sleep Research Society · 2025
    Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Deriving psychiatric symptom-based biomarkers from multivariate relationships between psychophysiological and biochemical measures.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022
    Article
  16. Article
  17. Article
  18. Article
  19. Obesity and Obstructive Sleep Apnea.Handbook of experimental pharmacology · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Ila MishraDepartment of Biology, Western Kentucky University, Bowling Green, Kentucky.
Keelee B PullumDepartment of Biology, Western Kentucky University, Bowling Green, Kentucky.
Domnique C ThayerDepartment of Biology, Western Kentucky University, Bowling Green, Kentucky.
Erica R PlummerDepartment of Biology, Western Kentucky University, Bowling Green, Kentucky.
Benjamin W ConkrightDepartment of Biology, Western Kentucky University, Bowling Green, Kentucky.
Andrew J MorrisDepartment of Pharmacology, University of Kentucky, Lexington, Kentucky.
Bruce F O'HaraDepartment of Biology, University of Kentucky, Lexington, Kentucky.
Gregory E DemasDepartment of Biology, Indiana University, Bloomington, Indiana.
Noah T AshleyDepartment of Biology, Western Kentucky University, Bowling Green, Kentucky.ORCID 0000-0002-9850-0681
Western Kentucky University · USUniversity of Kentucky · USIndiana University Bloomington · US

Funding

WKU Lead Faculty AwardP20GM103436 · NIGMS · UNIVERSITY OF LOUISVILLE · PI ERIC C ROUCHKA · 2012 to 2026
$60.1M
Sympathetic Regulation of Inflammation from Sleep FragmentationR15GM117534 · NIGMS · WESTERN KENTUCKY UNIVERSITY · PI ASHLEY, NOAH TODD · 2016 to 2021
$831k
NIGMS NIH HHS P20 GM103436NIGMS NIH HHS R15 GM117534
6 · The paper itself

Abstract

Sleep loss contributes to the development of cardiovascular, metabolic, and neurological disorders by promoting a systemic proinflammatory phenotype. The neuroendocrine-immune mechanisms contributing to such pathologies are poorly understood. The sympathetic nervous system (SNS) regulates immunity and is often activated following sleep disturbances. The aims of this study were to determine

Indexed as

Sympathectomy, ChemicalAnimalsCortisoneFemaleInflammationMiceMice, Inbred C57BLNorepinephrineOxidopamineSleep DeprivationStress, PhysiologicalSympatholyticsCortisoneNorepinephrineOxidopamineSympatholyticscytokinesinflammationmicesleep fragmentationsympathetic nervous system

Identifiers

PMID32130024
PMCPMC7191417
OpenAlexW3009706486

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.