ArticleArthritis & rheumatology (Hoboken, N.J.)2020
Asthma, Chronic Obstructive Pulmonary Disease, and Subsequent Risk for Incident Rheumatoid Arthritis Among Women: A Prospective Cohort Study.
Article in Arthritis & rheumatology (Hoboken, N.J.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
38 citing papers in PubMed, 3 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- Bidirectional association between rheumatoid arthritis and chronic obstructive pulmonary disease: a systematic review and meta-analysis.Frontiers in immunology · 2024Pooled it
- Prevalence and risk factors of bronchiectasis in rheumatoid arthritis: A systematic review and meta-analysis.Seminars in arthritis and rheumatism · 2021Pooled it
- A causal relationship between rheumatoid arthritis and bronchiectasis? A systematic review and meta-analysis.Chronic respiratory diseasePooled it
- Between Guidelines and Daily Practice: The Persistent Use of Parenteral Depot Corticosteroids in Germany.Clinical and translational allergy · 2026Article
- Rheumatoid arthritis and risk of lung diseases in East Asians and Europeans: Evidence from a Mendelian randomization study.SAGE open medicine · 2026Article
- Asthma, social isolation and loneliness, and risk of incident osteoarthritis.Arthritis research & therapy · 2025Article
- Article
- Rheumatoid arthritis, quantitative parenchymal lung features and mortality among smokers.Rheumatology (Oxford, England) · 2025Article
- Hospital-Treated Infections and 15-year Incidence of Musculoskeletal Disorders: A Large Population-Based Cohort Study.Clinical epidemiology · 2025Article
- Evolving understanding of autoimmune mechanisms and new therapeutic strategies of autoimmune disorders.Signal transduction and targeted therapy · 2024Review
- Bi-directional association of rheumatoid arthritis and chronic obstructive pulmonary disease: linking arthritis, inflammation, smoking, airways disease, and emphysema.Rheumatology (Oxford, England) · 2024Article
- Air Pollution and Rheumatoid Arthritis Risk and Progression: Implications for the Mucosal Origins Hypothesis and Climate Change for RA Pathogenesis.Current rheumatology reports · 2024Review
- Rheumatoid arthritis and changes on spirometry by smoking status in two prospective longitudinal cohorts.RMD open · 2024Article
- Gene-respiratory disease interactions for rheumatoid arthritis risk.Seminars in arthritis and rheumatism · 2023Article
- Effect of Chronic Rhinosinusitis on the Risk of Development of Rheumatoid Arthritis.Allergy, asthma & immunology research · 2023Article
- Increased risk of osteoarthritis in patients with atopic disease.Annals of the rheumatic diseases · 2023Article
- Clinical features of asthma with connective tissue diseases.The clinical respiratory journal · 2023Article
- Arthritis and incident pulmonary diseases in middle-aged and elderly Chinese: a longitudinal population-based study.Clinical rheumatology · 2023Article
- Occupational inhalable agents constitute major risk factors for rheumatoid arthritis, particularly in the context of genetic predisposition and smoking.Annals of the rheumatic diseases · 2023Article
- Association of rheumatoid arthritis with bronchial asthma and asthma-related comorbidities: A population-based national surveillance study.Frontiers in medicine · 2023Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
objectiveInflamed airways are hypothesized to contribute to rheumatoid arthritis (RA) pathogenesis due to RA-related autoantibody production, and smoking is the strongest environmental RA risk factor. However, the role of chronic airway diseases in RA development is unclear. We undertook this study to investigate whether asthma and chronic obstructive pulmonary disease (COPD) were each associated with RA.
methodsWe performed a prospective cohort study of 205,153 women in the Nurses' Health Study (NHS, 1988-2014) and NHSII (1991-2015). Exposures were self-reported physician-diagnosed asthma or COPD confirmed by validated supplemental questionnaires. The primary outcome was incident RA confirmed by medical record review by 2 rheumatologists. Covariates (including smoking pack-years/status) were assessed via biennial questionnaires. Multivariable hazard ratios (HRs) and 95% confidence intervals (CIs) for RA were estimated using Cox regression.
resultsWe identified 15,148 women with confirmed asthma, 3,573 women with confirmed COPD, and 1,060 incident RA cases during 4,384,471 person-years (median 24.0 years/participant) of follow-up in the NHS and NHSII. Asthma was associated with increased RA risk (HR 1.53 [95% CI 1.24-1.88]) compared to no asthma/COPD after adjustment for covariates, including smoking pack-years/status. Asthma remained associated with increased RA risk when analyzing only never-smokers (HR 1.53 [95% CI 1.14-2.05]). COPD was also associated with increased RA risk (HR 1.89 [95% CI 1.31-2.75]). The association of COPD with RA was most pronounced in the subgroup of ever-smokers age >55 years (HR 2.20 [95% CI 1.38-3.51]).
conclusionAsthma and COPD were each associated with increased risk of incident RA, independent of smoking status/intensity and other potential confounders. These results provide support for the hypothesis that chronic airway inflammation may be crucial in RA pathogenesis.
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