Evidence map›Paper›PMID 32129529›Full record

ArticleMagnetic resonance in medicine2020

Joint multi-contrast variational network reconstruction (jVN) with application to rapid 2D and 3D imaging.

Daniel Polak, Stephen Cauley, Berkin Bilgic, Enhao Gong, Peter Bachert, Elfar Adalsteinsson, Kawin Setsompop

Open access · hybridAbstract read
In one paragraph

Article in Magnetic resonance in medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 10 citations in OpenAlex.

  1. Combined ADC and TMagnetic resonance in medicine · 2026
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  13. FlowMRI-Net: A generalizable self-supervised 4D flow MRI reconstruction network.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Daniel PolakDepartment of Physics and Astronomy, Heidelberg University, Heidelberg, Germany.ORCID 0000-0001-9781-1528
Stephen CauleyDepartment of Radiology, A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA.
Berkin BilgicDepartment of Radiology, A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA.
Enhao GongSubtle Medical Inc, Menlo Park, CA, USA.
Peter BachertDepartment of Physics and Astronomy, Heidelberg University, Heidelberg, Germany.
Elfar AdalsteinssonDepartment of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
Kawin SetsompopDepartment of Radiology, A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA.
Harvard University · USGerman Cancer Research Center · DEHeidelberg University · DEMassachusetts Institute of Technology · US

Funding

MRI CORTICOGRAPHY: DEVELOPING NEXT GENERATION MICROSCALE HUMAN CORTEX MRI SCANNERU01EB025162 · NIBIB · UNIVERSITY OF CALIFORNIA BERKELEY · PI FEINBERG, DAVID ALAN, LIU, CHUNLEI · 2017 to 2021
$13.4M
Project 4P41EB015896 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 2012 to 2018
$9.8M
Next generation in-vivo diffusion imaging at submillimeter resolutionR01MH116173 · NIMH · STANFORD UNIVERSITY · PI Yogesh Rathi, Kawin Setsompop · 2018 to 2026
$6.2M
fMRI Technologies for Imaging at the Limit of Biological Spatiotemporal Resolution: Administrative SupplementR01EB019437 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI POLIMENI, JONATHAN RIZZO, SETSOMPOP, KAWIN · 2015 to 2024
$5.5M
MRI technology for restoring brain image quality for pediatric patients with metallic orthodontic hardwareR01EB028797 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI Berkin Bilgic, Jason P Stockmann · 2020 to 2026
$3.0M
Rapid MRI acquisition for pediatric low-grade gliomasR01EB020613 · NIBIB · STANFORD UNIVERSITY · PI SETSOMPOP, KAWIN · 2016 to 2019
$2.5M
A Storage Area Network for Structural and Functional Image AnalysisS10RR023401 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI FISCHL, BRUCE · 2009 to 2009
$2.0M
SILICON GRAPHICS PRISM EXTREME 128P/1TBS10RR023043 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI SORENSEN, ALMA GREGORY · 2006 to 2006
$1.5M
A 3.0 Tesla MRI System in a Neuroscience ICUS10RR019254 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI SORENSEN, ALMA GREGORY · 2004 to 2004
$500k
Computeserver Structural &Functional Image AnalysisS10RR019307 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI FISCHL, BRUCE · 2004 to 2004
$496k
NCRR NIH HHS S10 RR019254NCRR NIH HHS S10 RR019307NCRR NIH HHS S10 RR023043NCRR NIH HHS S10 RR023401NIBIB NIH HHS P41 EB015896NIBIB NIH HHS R01 EB019437NIBIB NIH HHS R01 EB020613NIBIB NIH HHS R01 EB028797NIBIB NIH HHS U01 EB025162NIMH NIH HHS R01 MH116173
6 · The paper itself

Abstract

purposeTo improve the image quality of highly accelerated multi-channel MRI data by learning a joint variational network that reconstructs multiple clinical contrasts jointly.

methodsData from our multi-contrast acquisition were embedded into the variational network architecture where shared anatomical information is exchanged by mixing the input contrasts. Complementary k-space sampling across imaging contrasts and Bunch-Phase/Wave-Encoding were used for data acquisition to improve the reconstruction at high accelerations. At 3T, our joint variational network approach across T1w, T2w and T2-FLAIR-weighted brain scans was tested for retrospective under-sampling at R = 6 (2D) and R = 4 × 4 (3D) acceleration. Prospective acceleration was also performed for 3D data where the combined acquisition time for whole brain coverage at 1 mm isotropic resolution across three contrasts was less than 3 min.

resultsAcross all test datasets, our joint multi-contrast network better preserved fine anatomical details with reduced image-blurring when compared to the corresponding single-contrast reconstructions. Improvement in image quality was also obtained through complementary k-space sampling and Bunch-Phase/Wave-Encoding where the synergistic combination yielded the overall best performance as evidenced by exemplary slices and quantitative error metrics.

conclusionBy leveraging shared anatomical structures across the jointly reconstructed scans, our joint multi-contrast approach learnt more efficient regularizers, which helped to retain natural image appearance and avoid over-smoothing. When synergistically combined with advanced encoding techniques, the performance was further improved, enabling up to R = 16-fold acceleration with good image quality. This should help pave the way to very rapid high-resolution brain exams.

Indexed as

Image Processing, Computer-AssistedImaging, Three-DimensionalMagnetic Resonance ImagingProspective StudiesRetrospective Studiesdeep learningJoint multi-contrast reconstructionparallel imagingWave-CAIPI

Identifiers

PMID32129529
PMCPMC7539238
OpenAlexW2980140658

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.