Evidence map›Paper›PMID 32128971›Full record

ReviewLiver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society2020

Physical Function, Physical Activity, and Quality of Life After Liver Transplantation.

Michael A Dunn, Shari S Rogal, Andres Duarte-Rojo, Jennifer C Lai

Open access · greenAbstract readReview
In one paragraph

Review in Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 2 pooled it
6.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 2 syntheses or guidelines pooled it, 120 citations in OpenAlex.

  1. Patient-reported outcome measures (PROMs) used among liver transplant recipients: a systematic review and methodological quality appraisal.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025
    Pooled it
  2. Pooled it
  3. Effects of Early Resistance Training After Liver Transplantation Procedures: A Randomized Controlled Pilot Trial.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2022
    Trial
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  5. Observational
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  10. Observational
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  13. Changes in nutritional status in hepatocellular carcinoma patients treated with sorafenib.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
  14. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Michael A DunnCenter for Liver Diseases, Department of Gastroenterology, University of Pittsburgh, Pittsburgh, PA.ORCID 0000-0002-0954-0498
Shari S RogalDepartment of Medicine, Pittsburgh, PA.ORCID 0000-0001-8184-1546
Andres Duarte-RojoCenter for Liver Diseases, Department of Gastroenterology, University of Pittsburgh, Pittsburgh, PA.ORCID 0000-0002-5377-9295
Jennifer C LaiDivision of Gastroenterology and Hepatology, Department of Medicine, University of California, San Francisco, CA.ORCID 0000-0003-2092-6380
University of Pittsburgh · USUniversity of California, San Francisco · US

Funding

Improving Pain Management and Opioid Safety for Patients with CirrhosisK23DA048182 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ROGAL, SHARI S · 2020 to 2023
$755k
NIDA NIH HHS K23 DA048182
6 · The paper itself

Abstract

Robust physical activity after liver transplantation is an important determinant of longterm health, similar in its importance to the value of pretransplant activity for withstanding the immediate stress of transplantation. Although transplantation normally enables rapid recovery of liver synthetic and metabolic functions, the recovery of physical capacity and performance to normal levels is delayed and often incomplete. Anatomic measurements of sarcopenia and the physical performance indicators of frailty both tend to improve slowly, and they may, in fact, decrease further in the posttransplant period, especially when the common extrahepatic drivers of muscle loss, such as the elements of the metabolic syndrome, persist or intensify after transplantation. Posttransplant exercise improves fitness, which is a conclusion based on 2 observational studies and 3 randomized trials that assessed endpoints of strength testing, energy expenditure in metabolic equivalents, and peak or maximal oxygen uptake. Importantly, 1 controlled trial found that exercise also improved quality of life (QOL) measured by the Short Form 36 survey, consistent with multiple reports of the value of social support and engagement in sports activity for improving posttransplant QOL. Developing evidence-based standards for post-liver transplant physical activity baseline testing and sustainment of intensity and quality is a key unmet need in transplant hepatology. At present, it is reasonable for transplant teams to assess fitness and design a tailored exercise program when a recipient is first discharged, to record and reinforce progress at all posttransplant visits, and to set realistic longterm performance goals that will often achieve recommended standards for the healthy general population.

Indexed as

Liver TransplantationSarcopeniaExerciseExercise TherapyHumansQuality of Life

Identifiers

PMID32128971
PMCPMC8063858
OpenAlexW3010104808

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.