Evidence map›Paper›PMID 32128892›Full record

ArticleJournal of veterinary internal medicine2020

Fecal microbiota in horses with asthma.

Mathilde Leclere, Marcio C Costa

Open access · goldAbstract readObservational Study, Veterinary
In one paragraph

Article in Journal of veterinary internal medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.5field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 43 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. The Microbiota and Equine Asthma: An Integrative View of the Gut-Lung Axis.Animals : an open access journal from MDPI · 2024
    Review
  9. Article
  10. Effects of concentrated fecal microbiota transplant on the equine fecal microbiota after antibiotic-induced dysbiosis.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2023
    Article
  11. Article
  12. Feeding aAnimals : an open access journal from MDPI · 2022
    Article
  13. Article
  14. Effects of Intravenous Antimicrobial Drugs on the Equine Fecal Microbiome.Animals : an open access journal from MDPI · 2022
    Article
  15. Review
  16. Article
  17. Fecal microbiota in horses with asthma.Journal of veterinary internal medicine · 2020
    Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Mathilde LeclereClinical Sciences Department, Université de Montréal, Québec, Canada.ORCID https://orcid.org/0000-0002-3910-0370
Marcio C CostaVeterinary Department of Biomedical Sciences, Université de Montréal, Québec, Canada.ORCID https://orcid.org/0000-0001-5067-7501
Université de Montréal · CAUniversité du Québec à Montréal · CA

Funding

Natural Sciences and Engineering Research Council of Canada 06090
6 · The paper itself

Abstract

backgroundGastrointestinal microbiota can be influenced by several factors, including diet and systemic inflammation, and in turn could act as a modulator of the allergic response. Fecal microbiota of horses with asthma has not been described. HYPOTHESIS/

objectivesAnalyze the bacterial fecal microbiota of horses with and without asthma under different environment and diet conditions, during both remission and exacerbation.

methodsProspective observational study. Feces from 6 asthmatic and 6 healthy horses were collected under 3 different conditions: on pasture, housed indoors receiving good quality hay ("good hay"), and housed indoors receiving poor quality hay ("dusty hay"). Sequencing was performed using an Illumina MiSeq platform and data were processed using the software mothur v.1.41.3 and LEfSe.

resultsIn horses with asthma, low-abundance bacteria were more affected by changes in environment and diet (ie, when horses were experiencing an exacerbation), as shown by changes in membership and results from the LEfSe analysis. There was a significant increase in the relative abundance of Fibrobacter in healthy horses eating hay, a change that was not observed in horses with asthma. CONCLUSIONS AND CLINICAL IMPORTANCE: The intestinal microbiota of horses with asthma does not adapt in the same way to changes in diet and environment compared to the microbiota of healthy horses. Mechanisms explaining how airway obstruction and inflammation could influence the intestinal microbiota and how in turn this microbiota could modulate systemic inflammation in asthmatic horses deserves further investigation.

Indexed as

AnimalsAsthmaBronchoalveolar Lavage FluidFecesFemaleHorse DiseasesHorsesMaleProspective Studiesgut-lung axisheaveshorsemicrobiomerecurrent airway obstruction

Identifiers

PMID32128892
PMCPMC7096608
OpenAlexW3010479002

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.