Observational studyCanadian journal of anaesthesia = Journal canadien d'anesthesie2020
Accuracy of the Clinical Frailty Scale for perioperative frailty screening: a prospective observational study.
Observational study in Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04783662 (Study of an Intraoperative Frontal Electroencephalographic Marker of Preoperative Frailty in Patients Over 65 Years of Age for Elective Non-cardiac Surgery.), which is not on this map. Cited by 14 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Study of an Intraoperative Frontal Electroencephalographic Marker of Preoperative Frailty in Patients Over 65 Years of Age for Elective Non-cardiac Surgery.
Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The effectiveness of clinical frailty assessment in older patients with Traumatic brain injury in predicting outcome and quality of life: a systematic review.Neurosurgical review · 2025Pooled it
- The Association Between the Clinical Frailty Scale and Adverse Health Outcomes in Older Adults in Acute Clinical Settings - A Systematic Review of the Literature.Clinical interventions in aging · 2023Pooled it
- Feasibility of preoperative patient self-assessed frailty: a single-centre pilot study.BJA open · 2026Article
- Comparison of the long-term prognostic value of different frailty instruments in older inpatients: a 5-year prospective cohort study.European journal of medical research · 2025Article
- 'Focus on Frailty': Co-Designing Digital Frailty Education with Healthcare Students.Journal of multidisciplinary healthcare · 2025Article
- The perioperative frailty index derived from the Chinese hospital information system: a validation study.BMC geriatrics · 2024Article
- Interrater reliability of the Clinical Frailty Scale in the anesthesia preadmission clinic.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2023Article
- Association Between Frailty and Antiseizure Medication Tolerability in Older Adults With Epilepsy.Neurology · 2023Article
- Prevalence and associated factors of frailty and sarcopenia in multiple system atrophy and progressive supranuclear palsy: a cross-sectional study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- Comparison of three frailty screening instruments for prediction of adverse outcomes among older adults in the emergency department.Geriatrics & gerontology international · 2022Article
- Frailty and Potentially Inappropriate Prescribing in Older People with Polypharmacy: A Bi-Directional Relationship?Drugs & aging · 2022Review
- Heterogeneity in functional status among moderately frail older adults: improving predictive performance using a modified approach of subgrouping the Clinical Frailty Scale.European geriatric medicine · 2021Article
- Translation and validation of the Korean version of the clinical frailty scale in older patients.BMC geriatrics · 2021Article
- Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePerioperative frailty increases postoperative complications, mortality, and new functional dependence. Despite this, routine perioperative frailty screening is not widespread. We aimed to assess the accuracy of the Clinical Frailty Scale (CFS) as a screening tool prior to anesthesia, and to determine which health domains are affected by frailty.
methodsIn a prospective, single-centre observational study, we enrolled 218 patients aged ≥ 65 yr undergoing elective and emergency surgery. The screening performance of the CFS was compared with the Edmonton Frail Scale, including the effect in individual frailty domains, and outcomes including discharge location and mortality.
resultsThe median [interquartile range] age of the enrolled subjects was 74 [69-80] yr and 24% of the patients were frail. The CFS and Edmonton scales were highly correlated (Spearman correlation coefficient, 0.81; 95% confidence interval [CI], 0.77 to 0.86), and in substantial agreement (kappa coefficient, 0.76; 95% CI, 0.70 to 0.81), with an area under the receiver operating characteristic curve of 0.91 (95% CI, 0.86 to 0.94) indicating excellent discrimination for the CFS in predicting frailty status based on the Edmonton scale. Frail patients had higher 30-day mortality (odds ratio, 5.26; 95% CI, 1.28 to 21.62), and were less likely to be discharged home. Frail patients had poorer health throughout frailty domains, including functional dependence (42% of frail vs 4% of non-frail patients; P < 0.001), malnutrition (48% vs 19%, P < 0.001), and poor physical performance (47% vs 7%, P < 0.001).
conclusionThe CFS is a valid and accurate tool to screen for perioperative frailty, which encompasses the spectrum of health-related domains.
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