ArticleEuropean heart journal2020
The 'Digital Twin' to enable the vision of precision cardiology.
Article in European heart journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07719621 (Implication of Albuminuria Reduction and Other Cardiorenal Effects on The Risk of Heart Failure in Patients With CKD and T2D), which is not on this map. Cited by 346 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Implication of Albuminuria Reduction and Other Cardiorenal Effects on The Risk of Heart Failure in Patients With CKD and T2D
Who cites it
346 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- From assistance to autonomy: AI agent systems in cardiovascular medicine-a review of paradigms, architectures, and clinical translation.Frontiers in cardiovascular medicine · 2026Pooled it
- Digital Twins and Health Care: an Umbrella Review.Journal of medical systems · 2025Pooled it
- A digital twin-enhanced decision support system improves time-in-range in type 1 diabetes: a randomized clinical trial.Scientific reports · 2025Trial
- Synthetic control methods for n-of-1 and parallel-group trials in Alzheimer's disease: A proof-of-concept study using the I-CONECT.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Trial
- Clinical trials in a dish: cardiometabolic drug development with biological and digital twins.The Journal of clinical investigation · 2026Review
- In Silico Clinical Trials in Drug Development: Virtual Patients, Applications, and Regulatory Convergence.Clinical pharmacology and therapeutics · 2026Review
- Precision Prevention for Health: The Global Alliance Framework for the Promotion of Physical Activity.Sports medicine (Auckland, N.Z.) · 2026Article
- Graph and Geometric Deep Learning for Intracranial Aneurysm Geometry and Hemodynamics: A Systematic Review with Implications for Neurovascular Implant Design and Evaluation.Life (Basel, Switzerland) · 2026Review
- CYP2D6 as an Emerging Endogenous Oxidative Stress Modulator in Cardiovascular Disease: Genetic, Pharmacological, and Redox Perspectives.Antioxidants (Basel, Switzerland) · 2026Review
- Digital twin for neurological conditions: a systematic scoping review.Biomedical engineering letters · 2026Review
- From Classical PKPD to Model-Informed Drug Development: Are "Digital Twins" a New Paradigm?Clinical pharmacology and therapeutics · 2026Article
- HeartSimSage: Attention-Enhanced Graph Neural Networks for Accelerating Cardiac Mechanics Modeling.Journal of computational physics · 2026Article
- Mechanical-medical convergence in heart failure: Artificial intelligence, finite-element modeling, and 3D printing for diagnosis and prognosis.Bioengineering & translational medicine · 2026Review
- Review
- Heart Failure sub-phenotyping and in-hospital and 28-day mortality prediction based on mean arterial pressure trajectory modeling.American heart journal plus : cardiology research and practice · 2026Article
- The Hodgkin-Huxley-Katz Prize Lecture: Heart digital twins: A new paradigm in arrhythmia medicine.The Journal of physiology · 2026Article
- Silicon Nitride Coatings on Titanium for Cardiovascular Applications: Interface Engineering, Hemocompatibility, and Translational Challenges.Materials (Basel, Switzerland) · 2026Review
- Envisioning the next steps for machine learning models in integrated cardiovascular-kidney-metabolic care.ESC heart failure · 2026Article
- Artificial Intelligence in Cardiac Surgery and Surgical Training: Opportunities, Risks, and Safeguards for Preserving Expertise.Journal of clinical medicine · 2026Review
- Advances and Clinical Translation Potentials of Functional Nanomaterials in Tissue Engineering.Bioengineering (Basel, Switzerland) · 2026Review
286 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
39 authors.
Funding
Abstract
Providing therapies tailored to each patient is the vision of precision medicine, enabled by the increasing ability to capture extensive data about individual patients. In this position paper, we argue that the second enabling pillar towards this vision is the increasing power of computers and algorithms to learn, reason, and build the 'digital twin' of a patient. Computational models are boosting the capacity to draw diagnosis and prognosis, and future treatments will be tailored not only to current health status and data, but also to an accurate projection of the pathways to restore health by model predictions. The early steps of the digital twin in the area of cardiovascular medicine are reviewed in this article, together with a discussion of the challenges and opportunities ahead. We emphasize the synergies between mechanistic and statistical models in accelerating cardiovascular research and enabling the vision of precision medicine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.