ArticleHuman reproduction open2020
The effects of hyaluronate-containing medium on human embryo attachment to endometrial epithelial cells
Article in Human reproduction open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- [Role of hyaluronic acid synthases in female infertility-related diseases].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025Review
- Article
- The modeling of human implantation and early placentation: achievements and perspectives.Human reproduction update · 2025Review
- Article
- A combined clinical and specific genes' model to predict live birth for in vitro fertilization and embryo transfer patients.BMC pregnancy and childbirth · 2023Article
- Hyaluronan-enriched transfer medium (HETM) can improve the implantation rate in morphologically poor euploid blastocyst transfer.Archives of gynecology and obstetrics · 2023Article
- Generating human blastoids modeling blastocyst-stage embryos and implantation.Nature protocols · 2023Review
- Article
- Three-dimensional culture models of human endometrium for studying trophoblast-endometrium interaction during implantation.Reproductive biology and endocrinology : RB&E · 2022Review
- Article
- Early human trophoblast development: from morphology to function.Cellular and molecular life sciences : CMLS · 2022Review
- Trophectoderm differentiation to invasive syncytiotrophoblast is promoted by endometrial epithelial cells during human embryo implantation.Human reproduction (Oxford, England) · 2022Article
- The expression and activity of Toll-like receptors in the preimplantation human embryo suggest a new role for innate immunity.Human reproduction (Oxford, England) · 2021Article
- Organoids to model the endometrium: implantation and beyond.Reproduction & fertility · 2021Review
- Embryo biosensing by uterine natural killer cells determines endometrial fate decisions at implantation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Clinical efficacy of hyaluronate-containing embryo transfer medium in IVF/ICSI treatment cycles: a cohort study.Human reproduction open · 2021Article
- Hyaluronan control of the primary vascular barrier during early mouse pregnancy is mediated by uterine NK cells.JCI insight · 2020Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
study questionDoes embryo transfer medium containing hyaluronate (HA) promote the attachment phase of human embryo implantation? SUMMARY ANSWER: HA-containing medium does not promote human blastocyst attachment to endometrial epithelial cells WHAT IS KNOWN ALREADY: Embryo transfer media containing high concentrations of HA are being used to increase implantation and live birth rates in IVF treatment, although the mechanism of action is unknown. STUDY DESIGN SIZE DURATION: Expression of HA-interacting genes in frozen-thawed oocytes/embryos was assessed by microarray analysis ( PARTICIPANTS/MATERIALS SETTING
methodsHuman embryos surplus to treatment requirements were donated with informed consent from several ART centres. Blastocyst-stage embryos were transferred at day 6 to confluent Ishikawa cell layers; some blastocysts were artificially hatched. Blastocyst attachment was monitored from 1 to 48 h, and the effects of blastocyst pre-treatment for 10 min with HA-containing medium were determined. MAIN RESULTS AND THE ROLE OF CHANCE: Human embryos expressed the HA receptor genes LIMITATIONS REASONS FOR CAUTION: Using an adenocarcinoma-derived cell line to model embryo-endometrium attachment may not fully recapitulate WIDER IMPLICATIONS OF THE
findingsMorphological trophectoderm grade can be correlated with blastocyst attachment STUDY FUNDING/COMPETING INTERESTS: This work was funded by a grant from the Wellbeing of Women, the NIHR Local Comprehensive Research Network and NIHR Manchester Clinical Research Facility, the Department of Health Scientist Practitioner Training Scheme, and the Ministry of Higher Education, The State of Libya. None of the authors has any conflict of interest to declare.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.