ArticleLaryngoscope investigative otolaryngology2020
Age-related change of auditory functional connectivity in Human Connectome Project data and tinnitus patients.
Article in Laryngoscope investigative otolaryngology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 4 citations in OpenAlex.
- Auditory Network Discoherence in Chronic Tinnitus.medRxiv : the preprint server for health sciences · 2026Article
- Disruptions of default mode network and precuneus connectivity associated with cognitive dysfunctions in tinnitus.Scientific reports · 2023Article
- Age-related change of auditory functional connectivity in Human Connectome Project data and tinnitus patients.Laryngoscope investigative otolaryngology · 2020Article
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5 authors at 2 institutions in 1 country.
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Abstract
backgroundWe reported that tinnitus patients showed reduced levels of auditory functional connectivity (FC) in comparison with normal hearing control subjects, and that we succeeded in objective diagnosis of tinnitus with 86% sensitivity and 74% specificity by focusing only on auditory-related FC. However, the age-related change of auditory FC is not clarified. In this study, we examine age-related change of the auditory FC using the database of Human Connectome Project (HCP) and compared with our database of tinnitus patients.
methodFrom the HCP database HCP Lifespan Pilot project, we studied five age groups, 8 to 9 years old, 14 to 15, 25 to 35, 45 to 55, and 65 to 75. We also applied our tinnitus patients' resting-state functional magnetic resonance imaging (fMRI) database, which is divided into three generations; 20 to 40 years old, 40 to 60, and 60 to 80 to compare with the HCP database. The resting state fMRI analyses were performed using the CONN toolbox version 18. As auditory-related regions, Heschl's gyrus, planum temporale, planum polare, operculum, insular cortex, and superior temporal gyrus were set as the regions of interest from our previous reports.
resultAuditory FC is strongest among adolescents and reduces with age. But the auditory FC of tinnitus patients were significantly less than those of HCP data in each generation.
conclusionAlthough auditory FC decreases with age, tinnitus patients have less auditory FC compared with age-matched controls. The age-matched cutoff values are necessary for an objective diagnosis of tinnitus with resting state fMRI.
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