ReviewLaryngoscope investigative otolaryngology2020
Botulinum toxin A is an effective therapeutic tool for the management of parotid sialocele and fistula: A systematic review.
Review in Laryngoscope investigative otolaryngology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Guidelines for the Use of Botulinum Toxin in Otolaryngology From the Korean Society of Laryngology, Phoniatrics and Logopedics Guideline Task Force.Clinical and experimental otorhinolaryngology · 2023Guideline
- An Extensive Lymphatic Malformation of the Parotid and Parotideo-Masseteric Region in an Adolescent: Nerve-Preserving Surgical Management and Postoperative Imaging Follow-Up: A Case Report.Children (Basel, Switzerland) · 2026Article
- A Stepwise Integrative Approach to Managing a Refractory Recurrent Cervical Sialocele in a Dog.Animals : an open access journal from MDPI · 2026Article
- Postoperative dietary management after parotid gland surgery in the absence of high-level evidence: consensus-based guidelines and a stepwise protocol for diet advancement.Frontiers in surgery · 2026Review
- Parotid ductoplasty for treatment of post-traumatic sialocele with ductal stenosis.Radiology case reports · 2025Article
- A novel approach for benign parotid tumors: a dual-focused strategy on functional preservation and aesthetics.World journal of surgical oncology · 2025Article
- Management of Parotid Fistula with Sodium Tetradecyl Sulphate and Intraparenchymal Botulinum Toxin Injection.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2025Article
- Intraglandular botulinum toxin in postoperative head and neck fistula: a retrospective analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Article
- The role of Botulinum Toxin for the Management of post Parotidectomy Sialocele: A Randomized Controlled Trial.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2025Article
- Partial Submandibular Gland Resection With Ultrasonic Dissector vs Electrocautery.Aesthetic surgery journal. Open forum · 2025Article
- A Six-Year Examination of the Influence of Surgical Technique and Intraoperative Intraglandular Clostridium Botulinum Toxin Application in Salivary Gland Tumor Operations.Journal of clinical medicine · 2024Article
- The Management of Salivary Fistulas.Seminars in plastic surgery · 2023Review
- Botulinum toxin A for the treatment of first bite syndrome-a systematic review.Gland surgery · 2022Review
- Botulinum toxin A is an effective therapeutic tool for the management of parotid sialocele and fistula: A systematic review.Laryngoscope investigative otolaryngology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesIn the management of parotid sialocele and fistula, various conservative and surgical methods have been described. Some studies have described the use of Botulinum toxin A (Botox A) for the management of parotid sialocele and fistula. This is a less invasive and potentially equally effective option. We therefore conducted a systematic review on the current body of literature relating to this specific use of Botox A.
methodsA search strategy was conducted in July 2019 using the following electronic databases: Cochrane Database of Systematic Reviews, EMBASE, Google Scholar, PubMed, Scopus, and Web of Science. A search of all articles from inception until 31 August 2019 was performed.
resultsLiterature searches of electronic databases identified 67 articles eligible for review, of which 15 fulfilled all criteria. These studies were small and in total only 47 patients were included. The majority of sialoceles and fistulas presented as a complication of surgery (77%) with the remaining cases occurring as a result of trauma. The typical age at presentation was between 32 and 88 years of age (mean age of 52 years). All patients were initially treated with and failed other conservative measures. Botox A injection was considered as a final conservative treatment option. The toxin was administered percutaneously in all cases of parotid sialocele and fistula. Dosage of Botox ranged from 10 to 200 units with majority of patients (58%) requiring only one injection. The overall success rate for patients treated with Botox A injections ranged between 70 and 100% for parotid sialoceles and fistulas.
conclusionBotox A injections are successful in the treatment of parotid sialoceles and fistulas and should be considered before the use of invasive conventional options. Further studies with larger numbers are needed to ratify this recommendation. Success rate for patients, treated with Botox A injection was between 70 and 100% for parotid sialocele and fistula. Patients who failed initial treatment with Botox A were re-administered with Botox A and eventually resolved.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.