ArticleScience advances2020
Singlet-filtered NMR spectroscopy.
Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 54 citations in OpenAlex.
- Single-scan ultra-selective probing on targeted components from overlapped NMR spectra.Magnetic resonance letters · 2026Article
- Live Metabolomics with NMR.Analytical chemistry · 2026Review
- NMR Based Methods for Metabolites Analysis.Analytical chemistry · 2025Review
- Long-lived states involving a manifold of fluorine-19 spins in fluorinated aliphatic chains.Magnetic resonance (Gottingen, Germany) · 2025Article
- Improved detection of magnetic interactions in proteins based on long-lived coherences.Communications chemistry · 2024Article
- Pure-Shift-Based Proton Magnetic Resonance Spectroscopy for High-Resolution Studies of Biological Samples.International journal of molecular sciences · 2024Article
- Large dynamics of a phase separating arginine-glycine-rich domain revealed via nuclear and electron spins.Nature communications · 2024Article
- Article
- Long-lived states of methylene protons in achiral molecules.Science advances · 2022Article
- Recent advances in the application of parahydrogen in catalysis and biochemistry.RSC advances · 2022Review
- Bimodal Fluorescence/Magnetic Resonance Molecular Probes with Extended Spin Lifetimes.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- Early Divergence in Misfolding Pathways of Amyloid-Beta Peptides.Chemphyschem : a European journal of chemical physics and physical chemistry · 2021Article
- Singlet-Contrast Magnetic Resonance Imaging: Unlocking Hyperpolarization with Metabolism*.Angewandte Chemie (International ed. in English) · 2021Article
- Mechanisms of coherent re-arrangement for long-lived spin order.Magnetic resonance (Gottingen, Germany) · 2021Review
- Magnetization Lifetimes Prediction and Measurements Using Long-Lived Spin States in Endogenous Molecules.Molecules (Basel, Switzerland) · 2020Article
- In vitro singlet state and zero-quantum encoded magnetic resonance spectroscopy: Illustration with N-acetyl-aspartate.PloS one · 2020Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Selectively studying parts of proteins and metabolites in tissue with nuclear magnetic resonance promises new insights into molecular structures or diagnostic approaches. Nuclear spin singlet states allow the selection of signals from chemical moieties of interest in proteins or metabolites while suppressing background signal. This selection process is based on the electron-mediated coupling between two nuclear spins and their difference in resonance frequency. We introduce a generalized and versatile pulsed NMR experiment that allows populating singlet states on a broad scale of coupling patterns. This approach allowed us to filter signals from proton pairs in the Alzheimer's disease-related b-amyloid 40 peptide and in metabolites in brain matter. In particular, for glutamine/glutamate, we have discovered a long-lived state in tissue without the typically required singlet sustaining by radiofrequency irradiation. We believe that these findings will open up new opportunities to study metabolites with a view on future in vivo applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.