ArticleScience advances2020
Glycosylation of immunoglobulin G is regulated by a large network of genes pleiotropic with inflammatory diseases.
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Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.
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83citing papers in PubMed
8.0field-weighted citation impact, top 2% of its field
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Who cites it
83 citing papers in PubMed, 138 citations in OpenAlex.
- Large glycomics datasets as a tool to understand the function of glycans.Nature chemical biology · 2026Review
- Interleukin-10 enhances IgG galactosylation and sialylation.Biomarker research · 2026Article
- Glycoproteomic and genetic analysis of N-glycosylation of complement component C3 reveals immune pathway regulation.Genome biology · 2026Article
- Mucosal glycans: key drivers of the development of inflammatory bowel disease and a potential new therapeutic target.Nature reviews. Gastroenterology & hepatology · 2026Review
- Causal associations of specific immunoglobulin G N-glycosylation subtypes with osteoporosis: A two-sample Mendelian randomization.Joint diseases and related surgery · 2026Article
- Immunoglobulin G in aging and cancer.Frontiers in immunology · 2026Review
- Genetically Predicted IgG N-Glycosylation Traits and Risk of Pre-Eclampsia or Eclampsia: A Two-Sample and Multivariable Mendelian Randomization Study.International journal of women's health · 2026Article
- Exploring the potential causal role of IgG N-glycosylation in urological cancers: a two-sample Mendelian randomization study using European ancestry datasets.Archives of medical science : AMS · 2026Article
- Quantitative Modeling of IgG N-Glycosylation Profiles from Population Data.International journal of molecular sciences · 2025Article
- Site-specific adaptive nanovesicles for oral insulin delivery.Science advances · 2025Article
- Amyloid-Related Imaging Abnormality (ARIA) Beyond the APOE-ε4 Allele.Chronic diseases and translational medicine · 2025Review
- Establishment of reference intervals for serum immunoglobulin GThe EPMA journal · 2025Article
- Efficient candidate drug target discovery through proteogenomics in a Scottish cohort.Communications biology · 2025Article
- Causal association between immunoglobulin G N-glycosylation patterns and diabetic complications: two-sample mendelian randomization.Diabetology & metabolic syndrome · 2025Article
- A genome-wide association study in 10,000 individuals links plasma N-glycome to liver disease and anti-inflammatory proteins.Nature communications · 2025Article
- Systems analysis unravels a common rural-urban gradient in immunological profile, function, and metabolic dependencies.Science advances · 2025Article
- Soluble Factors and Mechanisms Regulated by Sialylated IgG Signaling.Immunological reviews · 2025Review
- Integrative systems biology framework discovers common gene regulatory signatures in mechanistically distinct inflammatory skin diseases.NPJ systems biology and applications · 2025Article
- Role of Antibody Glycosylation in Health, Disease, and Therapy.Handbook of experimental pharmacology · 2025Review
- Immunoglobulin GFrontiers in immunology · 2025Article
23 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
53 authors at 16 institutions in 9 countries.
Lucija KlarićGenos Glycoscience Research Laboratory, Zagreb, Croatia.ORCID 0000-0003-3105-8929
Yakov A TsepilovInstitute of Cytology and Genetics, Siberian Branch of the Russian Academy of Science, 630090 Novosibirsk, Russia.ORCID 0000-0002-4931-6052
Chloe M StantonMRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Massimo ManginoDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.ORCID 0000-0002-2167-7470
Timo Tõnis SikkaEstonian Genome Center, University of Tartu, Tartu, Estonia.ORCID 0000-0002-6099-1083
Tõnu EskoEstonian Genome Center, University of Tartu, Tartu, Estonia.
Eugene PakhomovInstitute of Cytology and Genetics, Siberian Branch of the Russian Academy of Science, 630090 Novosibirsk, Russia.ORCID 0000-0003-0395-3168
Perttu SaloGenomics and Biomarkers Unit, Department of Health, National Institute for Health and Welfare (THL), Helsinki, Finland.ORCID 0000-0003-0265-0173
Joris DeelenMolecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Centre, Leiden, Netherlands.ORCID 0000-0003-4483-3701
Stuart J McGurnaghanMRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Toma KeserFaculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia.ORCID 0000-0003-2759-3742
Frano VučkovićGenos Glycoscience Research Laboratory, Zagreb, Croatia.ORCID 0000-0002-4845-0882
Ivo UgrinaGenos Glycoscience Research Laboratory, Zagreb, Croatia.ORCID 0000-0002-9882-2250
Jasminka KrištićGenos Glycoscience Research Laboratory, Zagreb, Croatia.
Ivan GudeljGenos Glycoscience Research Laboratory, Zagreb, Croatia.
Jerko ŠtambukGenos Glycoscience Research Laboratory, Zagreb, Croatia.
Rosina PlompLeiden University Medical Centre, Leiden, Netherlands.
Maja Pučić-BakovićGenos Glycoscience Research Laboratory, Zagreb, Croatia.ORCID 0000-0003-0866-623X
Tamara PavićFaculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia.ORCID 0000-0003-3174-120X
Marija VilajGenos Glycoscience Research Laboratory, Zagreb, Croatia.
Irena Trbojević-AkmačićGenos Glycoscience Research Laboratory, Zagreb, Croatia.ORCID 0000-0003-0106-0155
Camilla DrakeMRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Paula DobrinićDivision of Molecular Biology, Faculty of Science, University of Zagreb, Zagreb, Croatia.
Jelena MlinarecDivision of Molecular Biology, Faculty of Science, University of Zagreb, Zagreb, Croatia.
Barbara JelušićDivision of Molecular Biology, Faculty of Science, University of Zagreb, Zagreb, Croatia.ORCID 0000-0002-9130-6253
Anne RichmondMRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Maria TimofeevaColon Cancer Genetics Group, Cancer Research UK Edinburgh Centre and Medical Research Council Human Genetics Unit, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-2503-4253
Alexander K GrishchenkoInstitute of Cytology and Genetics, Siberian Branch of the Russian Academy of Science, 630090 Novosibirsk, Russia.ORCID 0000-0002-1052-6861
Julia DmitrievaUnit of Animal Genomics, WELBIO, GIGA-R and Faculty of Veterinary Medicine, University of Liège, Liège, Belgium.
Mairead L BerminghamMRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-0931-0051
Sodbo Zh SharapovInstitute of Cytology and Genetics, Siberian Branch of the Russian Academy of Science, 630090 Novosibirsk, Russia.ORCID 0000-0003-0279-4900
Susan M FarringtonColon Cancer Genetics Group, Cancer Research UK Edinburgh Centre and Medical Research Council Human Genetics Unit, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Evropi TheodoratouCentre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.ORCID 0000-0001-5887-9132
Hae-Won UhLeiden University Medical Centre, Leiden, Netherlands.ORCID 0000-0003-4195-7872
Marian BeekmanMolecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Centre, Leiden, Netherlands.ORCID 0000-0003-0585-6206
Eline P SlagboomMolecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Centre, Leiden, Netherlands.ORCID 0000-0002-2875-4723
Edouard LouisCHU-Liège and Unit of Gastroenterology, GIGA-R and Faculty of Medicine, University of Liège, Liège, Belgium.
Michel GeorgesUnit of Animal Genomics, WELBIO, GIGA-R and Faculty of Veterinary Medicine, University of Liège, Liège, Belgium.ORCID 0000-0003-4124-2375
Manfred WuhrerLeiden University Medical Centre, Leiden, Netherlands.ORCID 0000-0002-0814-4995
Helen M ColhounMRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Malcolm G DunlopColon Cancer Genetics Group, Cancer Research UK Edinburgh Centre and Medical Research Council Human Genetics Unit, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-3033-5851
Markus PerolaGenomics and Biomarkers Unit, Department of Health, National Institute for Health and Welfare (THL), Helsinki, Finland.ORCID 0000-0003-4842-1667
Krista FischerEstonian Genome Center, University of Tartu, Tartu, Estonia.ORCID 0000-0002-3521-0599
Ozren PolasekDepartment of Public Health, Faculty of Medicine, University of Split, Split, Croatia.
Harry CampbellCentre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Igor RudanCentre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
James F WilsonMRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.ORCID 0000-0001-5751-9178
Vlatka ZoldošDivision of Molecular Biology, Faculty of Science, University of Zagreb, Zagreb, Croatia.ORCID 0000-0002-1581-3720
Veronique VitartMRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-4991-3797
Tim SpectorDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.ORCID 0000-0002-9795-0365
Yurii S AulchenkoInstitute of Cytology and Genetics, Siberian Branch of the Russian Academy of Science, 630090 Novosibirsk, Russia.ORCID 0000-0002-7899-1575
Gordan LaucGenos Glycoscience Research Laboratory, Zagreb, Croatia.ORCID 0000-0003-1840-9560
Caroline HaywardMRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-9405-9550
Genos (Croatia) · HRInstitute of Genetics and Cancer · GBUniversity of Zagreb · HRLeiden University Medical Center · NLEdinburgh Cancer Research · GBNovosibirsk State University · RUUniversity of Liège · BEFinnish Institute for Health and Welfare · FIKing's College London · GBUniversity of Edinburgh · GBUniversity of Tartu · EEBroad Institute · USInstitute of Cytology and Genetics · RUKurchatov Institute · RUNHS Fife · GBPsychiatric Hospital Sveti Ivan · HR
Funding
Cancer Research UK 12076Cancer Research UK 18927Chief Scientist Office CZB/4/710Chief Scientist Office ETM/47Medical Research Council G0600237Medical Research Council G0600329Medical Research Council MC_PC_U127527198Medical Research Council MC_U127527198Medical Research Council MC_UU_00007/1Medical Research Council MC_UU_00007/10Medical Research Council MR/K018647/1Medical Research Council MR/R026408/1
Abstract
Effector functions of immunoglobulin G (IgG) are regulated by the composition of a glycan moiety, thus affecting activity of the immune system. Aberrant glycosylation of IgG has been observed in many diseases, but little is understood about the underlying mechanisms. We performed a genome-wide association study of IgG N-glycosylation (
Indexed as
Gene Expression RegulationAlgorithmsAllelesComputational BiologyGenetic LociGenome-Wide Association StudyGlycosylationHumansImmunoglobulin GInflammationLinkage DisequilibriumModels, GeneticPhenotypePolymorphism, Single NucleotidePolysaccharidesImmunoglobulin GPolysaccharides
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.