ArticleScience advances2020
Small-molecule activation of lysosomal TRP channels ameliorates Duchenne muscular dystrophy in mouse models.
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Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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46citing papers in PubMed
4.3field-weighted citation impact, top 6% of its field
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Who cites it
46 citing papers in PubMed, 59 citations in OpenAlex.
- How to Perform a Tracer Displacement BRET Assay for the TRPML1 Ion Channel.Bio-protocol · 2026Article
- Pathogen subversion of neuro-epidermal signaling impairs lysosomal function to disrupt collagen homeostasis in Caenorhabditis elegans.PLoS biology · 2026Article
- Established and emerging roles of lysosomal dysfunction in cardiac aging.Nature cardiovascular research · 2026Review
- Lysosomes and lysosomal dysfunction in ageing biology.Nature cell biology · 2026Review
- Pathogen Subversion of Neuro-Epidermal Signaling Impairs Lysosomal Function to Disrupt Collagen Homeostasis.bioRxiv : the preprint server for biology · 2026Article
- Tracheal nebulization of AAV-CRE for lung conditional knockout model construction and whole lung clearing.Biophysics reports · 2026Article
- ANXA11 suppression restores muscular function in the mdx mouse model of Duchenne muscular dystrophy (DMD).Nature communications · 2026Article
- TRPML1 inhibitor ML-SI1 suppresses prostate cancer through dual regulation of androgen receptor and polyamine metabolism.Frontiers in medicine · 2026Article
- Obestatin Treatment Counteracts Muscle Wasting by Reactivation of Autophagy in Duchenne Muscular Dystrophy.MedComm · 2026Article
- Autophagy-lysosomal pathway in neurodegeneration.Molecular neurodegeneration advances · 2026Review
- MCOLN1/TRPML1-MCOLN3/TRPML3 heteromer and its coupling to CaAutophagy · 2025Article
- Physiological functions and pharmacological targeting of transient receptor potential channels.Pharmacological reviews · 2025Review
- TRPML2 in distinct states reveals the activation and modulation principles of the TRPML family.Nature communications · 2025Article
- DG9 boosts PMO nuclear uptake and exon skipping to restore dystrophic muscle and cardiac function.Nature communications · 2025Article
- HEATR3 recognizes membrane rupture and facilitates xenophagy in response toProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Activation of lysosomal Ca2+ channels mitigates mitochondrial damage and oxidative stress.The Journal of cell biology · 2025Article
- Histone deacetylase 6 inhibition promotes microtubule acetylation and facilitates autophagosome-lysosome fusion in dystrophin-deficient mdx mice.Acta physiologica (Oxford, England) · 2025Article
- Article
- MCOLN1/TRPML1 in the lysosome: a promising target for autophagy modulation in diverse diseases.Autophagy · 2024Review
- TRPML1 activation ameliorates lysosomal phenotypes in CLN3 deficient retinal pigment epithelial cells.Scientific reports · 2024Article
Corrections and comments
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Authors and funding
20 authors at 3 institutions in 3 countries.
Lu YuDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, 4114 Biological Sciences Building, 1105 North University, Ann Arbor, MI 48109, USA.ORCID 0000-0002-6972-6489
Xiaoli ZhangDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, 4114 Biological Sciences Building, 1105 North University, Ann Arbor, MI 48109, USA.ORCID 0000-0002-0507-6317
Yexin YangDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, 4114 Biological Sciences Building, 1105 North University, Ann Arbor, MI 48109, USA.
Dan LiDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, 4114 Biological Sciences Building, 1105 North University, Ann Arbor, MI 48109, USA.
Kaiyuan TangDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, 4114 Biological Sciences Building, 1105 North University, Ann Arbor, MI 48109, USA.
Zifan ZhaoDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, 4114 Biological Sciences Building, 1105 North University, Ann Arbor, MI 48109, USA.
Wanwan HeDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, 4114 Biological Sciences Building, 1105 North University, Ann Arbor, MI 48109, USA.
Ce WangDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, 4114 Biological Sciences Building, 1105 North University, Ann Arbor, MI 48109, USA.ORCID 0000-0003-1932-0218
Nirakar SahooDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, 4114 Biological Sciences Building, 1105 North University, Ann Arbor, MI 48109, USA.ORCID 0000-0003-0669-3840
Kimber Converso-BaranDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-5436-5836
Carol S DavisDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.
Susan V BrooksDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0003-1954-967X
Anne BigotSorbonne Université, INSERM, AIM, Center for Research in Myology, UMRS974, GH Pitié-Salpétrière, 75651 Paris Cedex 13, France.ORCID 0000-0003-0337-5425
Raul CalvoNIH/NCATS/NCGC, 9800 Medical Center Drive, Rockville, MD 20850, USA.
Natalia J MartinezNIH/NCATS/NCGC, 9800 Medical Center Drive, Rockville, MD 20850, USA.
Noel SouthallNIH/NCATS/NCGC, 9800 Medical Center Drive, Rockville, MD 20850, USA.ORCID 0000-0003-4500-880X
Xin HuNIH/NCATS/NCGC, 9800 Medical Center Drive, Rockville, MD 20850, USA.
Juan MaruganNIH/NCATS/NCGC, 9800 Medical Center Drive, Rockville, MD 20850, USA.ORCID 0000-0002-3951-7061
Marc FerrerNIH/NCATS/NCGC, 9800 Medical Center Drive, Rockville, MD 20850, USA.
Haoxing XuDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, 4114 Biological Sciences Building, 1105 North University, Ann Arbor, MI 48109, USA.ORCID 0000-0003-3561-4654
University of Michigan · USNational Center for Advancing Translational Sciences · USInserm · FR
Funding
Structure, Composition, & Histology Core - Core BP30AR069620 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KARL J JEPSEN · 2016 to 2026
$8.4MThe Mucolipin TRP Ion ChannelsR01NS062792 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI XU, HAOXING · 2009 to 2018
$3.3MKinetic High Throughput Screening for Agonists and Inhibitors of the TRPML1 Ion channelZIATR000200 · NCATS · NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES · PI MARUGAN, JUAN · 2015 to 2022
$2.2MTRP Ca2+ Channels in the SkinR01AR060837 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI XU, HAOXING · 2012 to 2016
$1.7MIon channels in the tubulovesiclesR01DK115474 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI AKAABOUNE, MOHAMMED, DU, WANLU · 2018 to 2022
$1.4MNIAMS NIH HHS P30 AR069620NIAMS NIH HHS R01 AR060837NIDDK NIH HHS R01 DK115474NINDS NIH HHS R01 NS062792
Abstract
Duchenne muscular dystrophy (DMD) is a devastating disease caused by mutations in dystrophin that compromise sarcolemma integrity. Currently, there is no treatment for DMD. Mutations in transient receptor potential mucolipin 1 (ML1), a lysosomal Ca
Indexed as
AnimalsBiomarkersBiopsyDisease Models, AnimalDystrophinFluorescent Antibody TechniqueGene ExpressionLysosomesMiceMice, Inbred mdxMice, TransgenicMuscle, SkeletalMuscular Dystrophy, DuchenneMyocardiumTransient Receptor Potential ChannelsBiomarkersDystrophinTransient Receptor Potential Channels
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.