ArticleOpen forum infectious diseases2019
Impact of an Antimicrobial Stewardship Bundle for Uncomplicated Gram-Negative Bacteremia.
Article in Open forum infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Rapid Diagnostic Tests and Antimicrobial Stewardship Programs for the Management of Bloodstream Infection: What Is Their Relative Contribution to Improving Clinical Outcomes? A Systematic Review and Network Meta-analysis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024Pooled it
- Short-course versus long-course antibiotic treatment in patients with uncomplicated gram-negative bacteremia: A systematic review and meta-analysis.Journal of clinical pharmacy and therapeutics · 2021Pooled it
- Bacteraemia due to E.coli in urinary tract infections in adults: a prospective epidemiological study following implementation of guidelines in a regional hospital.BMC infectious diseases · 2025Article
- Proactive antimicrobial stewardship with real-time microbiological alerts improves management of bloodstream infections.JAC-antimicrobial resistance · 2025Article
- Variability in Durations of Therapy for Gram-Negative Bloodstream Infections and Factors Associated With Prolonged Durations.Open forum infectious diseases · 2025Article
- Standardization in the management of gram-negative bloodstream infections after implementation of a clinical care guideline at a large academic, safety-net institution: a quasi-experimental study.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2025Article
- Short versus long treatment duration for streptococcal bloodstream infection.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2025Article
- Impact of Implementing an Antimicrobial Stewardship Program for Optimizing Antibiotic Treatment in Gram-negative Bacilli Bacteremia.Infection & chemotherapy · 2024Article
- Antibiotic stewardship bundle for uncomplicated gram-negative bacteremia at an academic health system: a quasi-experimental study.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2024Article
- Impact of a Pro-Active Infectious Disease Consultation on the Management of a Multidrug-Resistant Organisms Outbreak in a COVID-19 Hospital: A Three-Months Quasi-Experimental Study.Antibiotics (Basel, Switzerland) · 2023Article
- Infectious disease physician characteristics and prescription of meropenem in the hospital.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2023Article
- Impact of specialty on the self-reported practice of using oral antibiotic therapy for definitive treatment of bloodstream infections.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2023Article
- Impact of a Multistep Bundles Intervention in the Management and Outcome of Gram-Negative Bloodstream Infections: A Single-Center "Proof-of-Concept" Study.Open forum infectious diseases · 2022Article
- Antibiotic Overuse and Stewardship at Hospital Discharge: The Reducing Overuse of Antibiotics at Discharge Home Framework.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Review
- Article
- Are Follow-Up Blood Cultures Useful in the Antimicrobial Management of Gram Negative Bacteremia? A Reappraisal of Their Role Based on Current Knowledge.Antibiotics (Basel, Switzerland) · 2020Review
- Is Early Oral Antimicrobial Switch Useful for Less Critically Ill Adults with Community-Onset Bacteraemia in Emergency Departments?Antibiotics (Basel, Switzerland) · 2020Article
- A Baker's Dozen of Top Antimicrobial Stewardship Intervention Publications in 2019.Open forum infectious diseases · 2020Review
- Oral β-Lactam Antibiotics vs Fluoroquinolones or Trimethoprim-Sulfamethoxazole for Definitive Treatment of Enterobacterales Bacteremia From a Urine Source.JAMA network open · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecent studies in gram-negative bacteremia (GNB) suggest that intravenous (IV) to oral (PO) switch and short treatment durations yield similar clinical outcomes and fewer adverse events. Antimicrobial stewardship program (ASP) bundled initiatives have been associated with improved clinical outcomes for bloodstream infections.
methodsThis single-center retrospective cohort evaluation included inpatient adults from 11/2014-10/2015 and 10/2017-9/2018 with GNB. The pre-ASP period was before the establishment of an ASP program. In the post period, the ASP promoted IV-to-PO switches, avoidance of repeat blood cultures, and short treatment durations for patients with uncomplicated GNB. The primary outcome was duration of antibiotic therapy. Secondary outcomes included process measures associated with the bundle and clinical outcomes.
resultsOne hundred thirty-seven patients met criteria for inclusion, with 51 patients in the pre group and 86 patients in the post group. Background characteristics were similar between groups. The median duration of therapy (interquartile range) was 14 (10-16) days in the pre group and 10 days (7-14) in the post group (
conclusionsAn ASP bundle for uncomplicated GNB was associated with reduced durations of therapy and earlier PO switch. These findings highlight the synergistic role of ASPs in optimizing antibiotic use and promoting patient safety.
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