ArticleOpen forum infectious diseases2019
Rapid Multiplex Testing for Upper Respiratory Pathogens in the Emergency Department: A Randomized Controlled Trial.
Article in Open forum infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02957136 (Randomized Clinical Trial of Multi-respiratory Pathogen Testing Versus Usual Care in Emergency Department), which is not on this map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Randomized Clinical Trial of Multi-respiratory Pathogen Testing Versus Usual Care in Emergency Department (ED) Patients With Upper Respiratory Symptoms
Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Evaluation of pharmacist guided intervention using procalcitonin and respiratory virus testing.The American journal of emergency medicine · 2023Trial
- Effects of a diagnostic stewardship intervention to de-implement widespread use of a rapid respiratory multiplex PCR test.Microbiology spectrum · 2026Article
- Health system implementation of clinical decision support to optimize respiratory pathogen profile utilization.Journal of clinical microbiology · 2026Article
- Impact of molecular point-of-care testing for respiratory pathogens on antibiotic use and clinical outcomes in acute respiratory tract infections: a systematic review and meta-analysis.EClinicalMedicine · 2026Article
- Impact of multiplex PCR point-of-care platform implementation for respiratory pathogen detection in an emergency department with high daily patient volume.Journal of clinical microbiology · 2026Article
- Changes in use of multiplex respiratory panel testing during the COVID-19 pandemic.Infection control and hospital epidemiology · 2024Observational
- Approaches to developing and implementing a molecular diagnostics stewardship program for infectious diseases: an ASM Laboratory Practices Subcommittee report.Journal of clinical microbiology · 2024Review
- Diagnostic stewardship to support optimal use of multiplex molecular respiratory panels: A survey from the Society for Healthcare Epidemiology of America Research Network.Infection control and hospital epidemiology · 2023Article
- The Interventions and Challenges of Antimicrobial Stewardship in the Emergency Department.Antibiotics (Basel, Switzerland) · 2023Review
- Point-of-Care and Rapid Tests for the Etiological Diagnosis of Respiratory Tract Infections in Children: A Systematic Review and Meta-Analysis.Antibiotics (Basel, Switzerland) · 2022Review
- Diagnostic Stewardship-The Impact of Rapid Diagnostic Testing for Paediatric Respiratory Presentations in the Emergency Setting: A Systematic Review.Children (Basel, Switzerland) · 2022Review
- Viral co-infections are associated with increased rates of hospitalization in those with influenza.Influenza and other respiratory viruses · 2022Article
- Detection of bacteria via multiplex PCR in respiratory samples of critically ill COVID-19 patients with suspected HAP/VAP in the ICU.Wiener klinische Wochenschrift · 2022Observational
- Point-of-care COVID-19 testing in the emergency department: current status and future prospects.Expert review of molecular diagnostics · 2021Review
- Paediatric Antimicrobial Stewardship for Respiratory Infections in the Emergency Setting: A Systematic Review.Antibiotics (Basel, Switzerland) · 2021Review
- Respiratory viral infections in pragmatically selected adults in intensive care units.Scientific reports · 2021Article
- PACIFIC: a lightweight deep-learning classifier of SARS-CoV-2 and co-infecting RNA viruses.Scientific reports · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAcute upper respiratory tract infections are a common cause of emergency department (ED) visits and often result in unnecessary antibiotic treatment.
methodsWe conducted a randomized clinical trial to evaluate the impact of a rapid, multipathogen respiratory panel (RP) test vs usual care (control). Patients were eligible if they were ≥12 months old, had symptoms of upper respiratory infection or influenza-like illness, and were not on antibiotics. The primary outcome was antibiotic prescription; secondary outcomes included antiviral prescription, disposition, and length of stay (ClinicalTrials.gov# NCT02957136).
resultsOf 191 patients enrolled, 93 (49%) received RP testing; 98 (51%) received usual care. Fifty-three (57%) RP and 7 (7%) control patients had a virus detected and reported during the ED visit (
conclusionsRapid RP testing was associated with a trend toward decreased antibiotic use, suggesting a potential benefit from more rapid viral tests in the ED. Future studies should determine if specific groups are more likely to benefit from testing and evaluate the relative cost and effectiveness of broad testing, focused testing, and a combined diagnostic and antimicrobial stewardship approach.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.