ArticleThe World Allergy Organization journal2020
IgE responses to multiple allergen components among school-aged children in a general population birth cohort in Tokyo.
Article in The World Allergy Organization journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 40 citations in OpenAlex.
- Allergic load and symptom severity in children with tic disorders: a cross-sectional study.European journal of pediatrics · 2026Article
- Population-specific patterns of IgE sensitization in Northwest China.Clinics (Sao Paulo, Brazil) · 2026Article
- Parental Age and Childhood Allergy Risk.JAMA network open · 2026Article
- An immunodominance perspective on a paradoxical phenomenon: discovery and modeling of ragweed and tree sensitization as negative predictors for high mugwort IgE reactivity.Frontiers in allergy · 2026Article
- Prevalence and Patterns of Allergen Sensitization in Southern China: A Retrospective Analysis of 18,777 Routine Checkup Participants in Shenzhen.Journal of asthma and allergy · 2026Article
- Inhalant Allergen Sensitization: Prevalence, Risk Factors, and Geographic Variation in the USA.International archives of allergy and immunology · 2026Article
- Distinct regional allergen sensitization patterns in pediatric populations: A comparative latent class analysis of multiple antigen simultaneous test-derived sensitization profiles in Japan and Taiwan.Asia Pacific allergy · 2025Article
- Prevalence and sensitization of pollen-food allergy syndrome among adolescents in Tokyo.The journal of allergy and clinical immunology. Global · 2025Article
- Gender and Age-Related Trends in Inhalant Allergen Sensitization in Lithuania: A Cross-Sectional Study.International journal of molecular sciences · 2025Article
- Assessing diagnostic tests for shrimp allergy in children: A multicenter trial.The journal of allergy and clinical immunology. Global · 2025Article
- Surveys on the prevalence of pediatric asthma in Japan: A comparison between the 1982, 1992, 2002, 2012, and 2022 surveys conducted in the same region using the same methodology (WJSAAC PhaseⅠ∼Ⅴ).The World Allergy Organization journal · 2025Article
- Exploring geographical variances in component-resolved diagnosis within the Asia-Pacific region.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025Review
- Association between allergen-specific immunoglobulin E sensitization, allergic rhinitis symptoms, and quality of life in school-aged children.Scientific reports · 2024Article
- Distinct IgE sensitization profiles in chronic urticaria: a comparative study with classic allergic diseases.Frontiers in immunology · 2024Article
- Decreased Basophil Activation against House Dust Mite after Japanese Cedar Pollen Subcutaneous Immunotherapy: A Retrospective Study.International archives of allergy and immunology · 2024Article
- A genome-wide association study for allergen component sensitizations identifies allergen component-specific and allergen protein group-specific associations.The journal of allergy and clinical immunology. Global · 2023Article
- Sensitization pattern to environmental allergens in a Japanese population.The journal of allergy and clinical immunology. Global · 2023Article
- Pollen Food Allergy Syndrome in Japanese Children and Adolescents: Risk Factors and Pollen Sensitisation.Journal of immunology research · 2023Article
- Childhood blood eosinophils and symptoms of allergic disorders: a cross-sectional study in Southern China.Annals of medicine · 2022Article
- Pollen Food Allergy Syndrome in Allergic March.Nutrients · 2022Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundResponse patterns to allergen components among Japanese children have not been studied extensively.
objectiveOur aim was to examine the differences in sensitization patterns at ages 5 years and 9 years to identify longitudinal changes in the degree and patterns of sensitization in a birth cohort of Japanese children.
methodsOur study enrolled 984 children at aged 5 years between 2008 and 2010, and 729 children aged 9 years between 2012 and 2014. Allergic diseases were assessed using the ISAAC and UK Working Party's Diagnostic Criteria. Serum-specific IgE titers to allergen components were measured by multiplex array ImmunoCAP ISAC when the children were aged 5 and 9 years. Principal component analysis (PCA) was performed to characterize IgE sensitization to allergen components.
resultsThe prevalence of allergic rhinitis increased considerably over time (10.6%-31.2%). Furthermore, the sensitization prevalence to allergen-specific IgE (sIgE) also increased from 57.8% at age 5 years to 74.8% at age 9 years. IgE sensitization prevalence to Der f 1 (mites) was 42.1% at age 5 years and 54.3% at age 9 years. Furthermore, children were highly sensitized to Cry j 1 (Japanese cedar) (32.8% at age 5 years and 57.8% at age 9 years). Principle component analysis showed that sensitization to PR-10 cross-reactive components was independent of sensitization to mite and that no children acquired sensitization to pollen before acquiring sensitization to mite.
conclusionsThe prevalence of allergic rhinitis and related allergen components increased from age 5 years to age 9 years in Japanese children.
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