ArticleAfrican health sciences2019
Serum levels of copper, zinc and disease severity scores in sickle cell disease patients in Benin City, Nigeria.
Article in African health sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- Zinc level and its impact on the phenotype of sickle cell disease.Annals of hematology · 2025Trial
- A Narrative Review of Zinc Deficiency-Associated Anemia.Hematology reports · 2026Review
- Article
- Modulatory role of welding fumes on serum zinc and copper levels and oxidative stress markers among welders: Considering smoking as a possible implication.Toxicology reports · 2024Article
- Zinc in Human Health and Infectious Diseases.Biomolecules · 2022Review
- Zinc, Magnesium, and Copper Levels in Patients with Sickle Cell Disease: A Systematic Review and Meta-analysis.Avicenna journal of medicine · 2022Review
- Nutritional perspectives on sickle cell disease in Africa: a systematic review.BMC nutrition · 2021Article
- Editorial.African health sciences · 2019Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMicronutrient deficiency is recognized in sickle cell anaemia (SCA) but it is not known for certain whether changes in zinc, copper and copper-to-zinc ratio are associated with Sickle cell disease severity scores.
objectiveTo compare serum levels of copper, zinc and copper-to-zinc ratio in SCA subjects with control group and correlate the variables with objective disease severity scores.
methodsSerum copper and zinc were determined in 100 SCA patients and 50 controls using kits supplied by Centronic, Germany. Unpaired Students't-test was used to compare the variables between SCA patients in steady clinical state, vaso-occlusive crisis and controls, while Spearman correlation coefficient was used to associate the parameters with disease severity scores.
resultsSerum copper level was higher (P=0.008) in SCA patients than controls, while serum zinc level was lower (P<0.001) in SCA patients than controls. The copper/zinc ratio was higher (P<0.001) in SCA patients than controls. Significantly higher (P<0.001) copper and lower (P<0.001) zinc levels were observed in patients in vaso-occlusive crisis than in steady clinical state. Zinc correlated inversely (r=-0.2743; P=0.006) while copper-to-zinc ratio correlated positively with disease severity scores.
conclusionCopper-to-zinc ratio may be an indicator of disease severity in SCA patients.
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