ArticleAnnals of gastroenterology
Efficacy of Hemospray in non-variceal upper gastrointestinal bleeding: a systematic review with meta-analysis.
Article in Annals of gastroenterology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Therapeutic Upper Gastrointestinal Endoscopy in Pediatric Gastroenterology.Frontiers in pediatrics · 2021Pooled it
- Endoscopic Application of Tranexamic Acid and Sucralfate in Upper Gastrointestinal Bleeding: A Randomized Controlled Trial.Clinical and translational gastroenterology · 2026Trial
- Efficacy of hemostatic powder for non-variceal gastrointestinal bleeding: a systematic review and meta-analysis of randomized trials.Therapeutic advances in gastroenterology · 2026Article
- Visceral Perforation Following Hemostatic Powder TC-325 Application in a Patient With Gastric Cancer: A Case Report.Cureus · 2025Article
- Current status and clinical outcome of endoscopic hemostatic powder in gastrointestinal bleeding: a retrospective multicenter study.Clinical endoscopy · 2024Article
- Haemostatic spray in the management of acute nonvariceal upper gastrointestinal bleeding in children: A single-centre experience in Singapore.JPGN reports · 2024Article
- Review
- Turn over the new leaf of the treatment in peptic ulcer bleeding: a review of the literature.Therapeutic advances in gastroenterology · 2024Review
- Topical hemostatic agents in the management of upper gastrointestinal bleeding: a meta-analysis.Endoscopy international open · 2023Article
- TC-325 hemostatic powder in the management of upper gastrointestinal malignant bleeding: a randomized controlled trial.Endoscopy international open · 2022Article
- Comparison of PuraStat self-assembling peptide hydrogel versus mineral-based Hemospray for endoscopic hemostasis of upper and lower gastrointestinal lesions in pigs.Frontiers in gastroenterology (Lausanne, Switzerland) · 2022Article
- Management of Non-Variceal Upper GI Bleeding in the Geriatric Population: An Update.Current gastroenterology reports · 2021Review
- Article
- Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecently, amongst other hemostatic modalities, Hemospray (TC-325) has emerged as an effective method for managing patients with non-variceal upper gastrointestinal bleeding (GIB). We conducted this systematic review and meta-analysis to assess the efficacy of Hemospray in patients with non-variceal upper GIB.
methodsOur primary outcomes were clinical and technical success; secondary outcomes were aggregate rebleeding, early rebleeding, delayed rebleeding, refractory bleeding, mortality, and treatment failure. A meta-analysis of proportions was conducted for all reported primary and secondary outcomes. A relative risk meta-analysis was conducted for studies reporting direct comparisons between Hemospray and other hemostatic measures.
resultsA total of 20 studies with 1280 patients were included in the final analysis. Technical success of Hemospray was seen in 97% of cases (95% confidence interval [CI] 94-98%,
conclusionHemospray is safe, effective and non-inferior to traditional hemostatic measures for the management of non-variceal upper GIB, and can thus be used as an alternative option.
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