Evidence map›Paper›PMID 32127612›Full record

ArticleScientific reports2020

High-Dose Melatonin and Ethanol Excipient Combined with Therapeutic Hypothermia in a Newborn Piglet Asphyxia Model.

Nicola J Robertson, Ingran Lingam, Christopher Meehan, Kathryn A Martinello, Adnan Avdic-Belltheus, Liane Stein, Mohamed Tachrount, David Price, Magdalena Sokolska, Alan Bainbridge and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 3 pooled it
10.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 3 syntheses or guidelines pooled it, 50 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Efficacy of melatonin in term neonatal models of perinatal hypoxia-ischaemia.Annals of clinical and translational neurology · 2022
    Pooled it
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  10. Article
  11. Stay cool and keep moving forwards.Pediatric research · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 4 countries.

Nicola J RobertsonUniversity College London, London, WC1E 6HX, UK. n.robertson@ucl.ac.uk.
Ingran LingamUniversity College London, London, WC1E 6HX, UK.
Christopher MeehanUniversity College London, London, WC1E 6HX, UK.
Kathryn A MartinelloUniversity College London, London, WC1E 6HX, UK.
Adnan Avdic-BelltheusUniversity College London, London, WC1E 6HX, UK.
Liane SteinUniversity College London, London, WC1E 6HX, UK.
Mohamed TachrountUniversity College London, London, WC1E 6HX, UK.
David PriceUniversity College London Hospitals NHS Trust, London, UK.
Magdalena SokolskaUniversity College London Hospitals NHS Trust, London, UK.
Alan BainbridgeUniversity College London Hospitals NHS Trust, London, UK.
Mariya HristovaUniversity College London, London, WC1E 6HX, UK.
Bobbi FleissRMIT, Melbourne, Australia.
Boris W KramerUniversity of Maastricht, Maastricht, The Netherlands.
Pierre GressensINSERM, Paris, France.
Xavier GolayUniversity College London, London, WC1E 6HX, UK.
University College London · GBUniversity College London Hospitals NHS Foundation Trust · GBInserm · FRMaastricht University · NLRMIT University · AU

Funding

Medical Research Council MR/M006743/1
6 · The paper itself

Abstract

With the current practice of therapeutic hypothermia for neonatal encephalopathy, disability rates and the severity spectrum of cerebral palsy are reduced. Nevertheless, safe and effective adjunct therapies are needed to optimize outcomes. This study's objective was to assess if 18 mg/kg melatonin given rapidly over 2 h at 1 h after hypoxia-ischemia with cooling from 1-13 h was safe, achieved therapeutic levels within 3 h and augmented hypothermic neuroprotection. Following hypoxia-ischemia, 20 newborn piglets were randomized to: (i) Cooling 1-13 h (HT; n = 6); (ii) HT+ 2.5% ethanol vehicle (HT+V; n = 7); (iii) HT + Melatonin (HT+M; n = 7). Intensive care was maintained for 48 h; aEEG was acquired throughout, brain MRS acquired at 24 and 48 h and cell death (TUNEL) evaluated at 48 h. There were no differences for insult severity. Core temperature was higher in HT group for first hour after HI. Comparing HT+M to HT, aEEG scores recovered more quickly by 19 h (p < 0.05); comparing HT+V to HT, aEEG recovered from 31 h (p < 0.05). Brain phosphocreatine/inorganic phosphate and NTP/exchangeable phosphate were higher at 48 h in HT+M versus HT (p = 0.036, p = 0.049 respectively). Including both 24 h and 48 h measurements, the rise in Lactate/N-acetyl aspartate was reduced in white (p = 0.030) and grey matter (p = 0.038) after HI. Reduced overall TUNEL positive cells were observed in HT+M (47.1 cells/mm

Indexed as

Hypothermia, InducedAnimalsAnimals, NewbornAsphyxiaDose-Response Relationship, DrugDrug InteractionsElectroencephalographyEthanolMelatoninSwineTissue DistributionEthanolMelatonin

Identifiers

PMID32127612
PMCPMC7054316
OpenAlexW3009479693

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.