ArticleScientific reports2020
G-protein signaling is required for increasing germline stem cell division frequency in response to mating in Drosophila males.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- Homologous recombination is essential for DNA damage-induced regeneration of Drosophila testis germline stem cells.Development (Cambridge, England) · 2026Article
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- The Gα GOA-1/GNAO1 non-autonomously promotes germline stem cell quiescence in feminizedmicroPublication biology · 2026Article
- Article
- Article
- Mating reconciles fitness and fecundity by switching diet preference in flies.Nature communications · 2024Article
- Mating-induced Ecdysone in the testis disrupts soma-germline contacts and stem cell cytokinesis.Development (Cambridge, England) · 2024Article
- Mating-induced ecdysone in the testis disrupts soma-germline contacts and stem cell cytokinesis.bioRxiv : the preprint server for biology · 2023Article
- Article
- Pvr regulates cyst stem cell division in the Drosophila testis niche, and has functions distinct from Egfr.Cells & development · 2023Article
- Review
- GPCRs Are Optimal Regulators of Complex Biological Systems and Orchestrate the Interface between Health and Disease.International journal of molecular sciences · 2021Review
- The trade-off between investment in weapons and fertility is mediated through spermatogenesis in the leaf-footed cactus bugEcology and evolution · 2021Article
- Regulation of Mating-Induced Increase in Female Germline Stem Cells in the Fruit FlyFrontiers in physiology · 2021Review
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adult stem cells divide to renew the stem cell pool and replenish specialized cells that are lost due to death or usage. However, little is known about the mechanisms regulating how stem cells adjust to a demand for specialized cells. A failure of the stem cells to respond to this demand can have serious consequences, such as tissue loss, or prolonged recovery post injury. Here, we challenge the male germline stem cells (GSCs) of Drosophila melanogaster for the production of specialized cells, sperm cells, using mating experiments. We show that repeated mating reduced the sperm pool and increased the percentage of GSCs in M- and S-phase of the cell cycle. The increase in dividing GSCs depended on the activity of the highly conserved G-proteins. Germline expression of RNA-Interference (RNA-i) constructs against G-proteins, or a dominant negative G-protein eliminated the increase in GSC division frequency in mated males. Consistent with a role for the G-proteins in regulating GSC division frequency, RNA-i against seven out of 35 G-protein coupled receptors (GPCRs) within the germline cells also eliminated the capability of males to increase the numbers of dividing GSCs in response to mating.
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