ArticleScientific reports2020
Dual dynamics of mitochondrial permeability transition pore opening.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 51 citations in OpenAlex.
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- Role of mitochondria in neuronal function and survival in the enteric and central nervous systems.Cellular and molecular life sciences : CMLS · 2026Review
- Density gradient centrifugation versus swim-up for selecting spermatozoa with improved redox activity, calcium status, and DNA integrity in an established rat model of varicocele-induced infertility.Frontiers in cell and developmental biology · 2026Article
- Intracellular Calcium as a Regulator of Polarization and Target Reprogramming of Macrophages.International journal of molecular sciences · 2025Review
- Cell Painting of insect gut cells for exploration of molecular responses of insect epithelia to insecticides.In vitro cellular & developmental biology. Animal · 2025Article
- Neuronal Injury after Ischemic Stroke: Mechanisms of Crosstalk Involving Necroptosis.Journal of molecular neuroscience : MN · 2025Review
- Spiropiperidine-Based Oligomycin-Analog Ligands To Counteract the Ischemia-Reperfusion Injury in a Renal Cell Model.Journal of medicinal chemistry · 2024Article
- Mechanism and treatment of intracerebral hemorrhage focus on mitochondrial permeability transition pore.Frontiers in molecular neuroscience · 2024Review
- Pyrazolo[4,3-International journal of molecular sciences · 2023Article
- Crosstalk between adenine nucleotide transporter and mitochondrial swelling: experimental and computational approaches.Cell biology and toxicology · 2023Article
- The Role of Mitochondria-Targeting miRNAs in Intracerebral Hemorrhage.Current neuropharmacology · 2023Review
- Glucose fluctuation promotes mitochondrial dysfunctions in the cardiomyocyte cell line HL-1.PloS one · 2023Article
- CC-4066 therapy delivered to kidneys during cold storage and assessed with normothermic reperfusion is feasible and safe.Frontiers in transplantation · 2023Article
- Mitochondria: one of the vital hubs for molecular hydrogen's biological functions.Frontiers in cell and developmental biology · 2023Review
- Article
- Lycopene: a therapeutic strategy against coronavirus disease 19 (COVID- 19).Inflammopharmacology · 2022Review
- Common methods in mitochondrial research (Review).International journal of molecular medicine · 2022Article
- Effects of Fu's subcutaneous needling on mitochondrial structure and function in rats with sciatica.Molecular pain · 2022Article
- Melatonin-Induced Postconditioning Suppresses NMDA Receptor through Opening of the Mitochondrial Permeability Transition Pore via Melatonin Receptor in Mouse Neurons.International journal of molecular sciences · 2022Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mitochondria play an essential role in bioenergetics and cellular Ca[Formula: see text] handling. The mitochondrial permeability transition pore (mPTP) is a non-specific channel located in the inner mitochondrial membrane. Long-lasting openings of the pore allow the rapid passage of ions and large molecules, which can result in cell death. The mPTP also exhibits transient, low conductance openings that contribute to Ca[Formula: see text] homeostasis. Although many regulators of the pore have been identified, none of them uniquely governs the passage between the two operating modes, which thus probably relies on a still unidentified network of interactions. By developing a core computational model for mPTP opening under the control of mitochondrial voltage and Ca[Formula: see text], we uncovered the existence of a positive feedback loop leading to bistability. The characteristics of the two stable steady-states correspond to those of the two opening states. When inserted in a full model of Ca[Formula: see text] handling by mitochondria, our description of the pore reproduces observations in mitochondrial suspensions. Moreover, the model predicted the occurrence of hysteresis in the switching between the two modes, upon addition and removal of free Ca[Formula: see text] in the extra-mitochondrial medium. Stochastic simulations then confirmed that the pore can undergo transient openings resembling those observed in intact cells.
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