Evidence map›Paper›PMID 32127545›Full record

ArticleNature communications2020

Effects of route of administration on oxytocin-induced changes in regional cerebral blood flow in humans.

D A Martins, N Mazibuko, F Zelaya, S Vasilakopoulou, J Loveridge, A Oates, S Maltezos, M Mehta, S Wastling, M Howard and 6 more

Erratum issuedOpen access · goldAbstract readControlled Clinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 67 papers.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
19.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 127 citations in OpenAlex.

  1. Trial
  2. Oxytocin Amplifies Negative Response to Ambiguity in Adolescent Females With and Without Eating Disorders.European eating disorders review : the journal of the Eating Disorders Association · 2025
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7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

D A MartinsDepartment of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
N MazibukoDepartment of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
F ZelayaDepartment of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
S VasilakopoulouDepartment of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
J LoveridgeDepartment of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
A OatesSouth London and Maudsley NHS Foundation Trust, London, UK.
S MaltezosAdult Autism and ADHD Service, South London and Maudsley NHS Foundation Trust, London, UK.
M MehtaDepartment of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0003-1152-5323
S WastlingDepartment of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
M HowardDepartment of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0002-9359-3057
G McAlonanDepartment of Forensic and Neurodevelopmental Science (SM), Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
D MurphyDepartment of Forensic and Neurodevelopmental Science (SM), Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0002-6664-7451
S C R WilliamsDepartment of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
A FotopoulouDepartment of Clinical, Educational and Health Psychology, University College London, London, UK.
U SchuschnigPARI GmbH, Gräfelfing, Germany.
Y PaloyelisDepartment of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. yannis.paloyelis@kcl.ac.uk.ORCID http://orcid.org/0000-0002-4029-3720
King's College London · GBSouth London and Maudsley NHS Foundation Trust · GBUniversity College London · GB

Funding

Medical Research Council MR/N026063/1Medical Research Council MR/N026969/1
6 · The paper itself

Abstract

Could nose-to-brain pathways mediate the effects of peptides such as oxytocin (OT) on brain physiology when delivered intranasally? We address this question by contrasting two methods of intranasal administration (a standard nasal spray, and a nebulizer expected to improve OT deposition in nasal areas putatively involved in direct nose-to-brain transport) to intravenous administration in terms of effects on regional cerebral blood flow during two hours post-dosing. We demonstrate that OT-induced decreases in amygdala perfusion, a key hub of the OT central circuitry, are explained entirely by OT increases in systemic circulation following both intranasal and intravenous OT administration. Yet we also provide robust evidence confirming the validity of the intranasal route to target specific brain regions. Our work has important translational implications and demonstrates the need to carefully consider the method of administration in our efforts to engage specific central oxytocinergic targets for the treatment of neuropsychiatric disorders.

Indexed as

Administration, IntranasalAdministration, IntravenousAdultAmygdalaBrainCerebrovascular CirculationDouble-Blind MethodHeart RateHumansMagnetic Resonance ImagingMaleNebulizers and VaporizersOxytocinPlacebosYoung AdultOxytocinPlacebos

Identifiers

PMID32127545
PMCPMC7054359
OpenAlexW3009941151

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.