Evidence map›Paper›PMID 32127472›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Regulation of B cell receptor-dependent NF-κB signaling by the tumor suppressor KLHL14.

Jaewoo Choi, James D Phelan, George W Wright, Björn Häupl, Da Wei Huang, Arthur L Shaffer, Ryan M Young, Zhuo Wang, Hong Zhao, Xin Yu and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 54 citations in OpenAlex.

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  10. Genotype from Phenotype: Using CRISPR Screens to Dissect Lymphoma Biology.Methods in molecular biology (Clifton, N.J.) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Jaewoo ChoiLymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
James D PhelanLymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
George W WrightBiometric Research Branch, Division of Cancer Diagnosis and Treatment, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Björn HäuplDepartment of Medicine II, Hematology/Oncology, Goethe University, 60590 Frankfurt, Germany.
Da Wei HuangLymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Arthur L ShafferLymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Ryan M YoungLymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Zhuo WangLymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Hong ZhaoLymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Xin YuLymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Thomas OellerichDepartment of Medicine II, Hematology/Oncology, Goethe University, 60590 Frankfurt, Germany.
Louis M StaudtLymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; lstaudt@mail.nih.gov.
National Cancer Institute · USCenter for Cancer Research · USFrankfurt Cancer Institute · DENational Institutes of Health · US

Funding

RNA interference-based screens for molecular targets in cancerZIABC011007 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI STAUDT, LOUIS · 2009 to 2025
$21.0M
Oncogenic mechanisms and molecular targets in lymphomaZIABC011008 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI STAUDT, LOUIS · 2009 to 2025
$21.0M
Identifying novel modes of oncogenic signaling in multiple myelomaZIABC011999 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI YOUNG, RYAN · 2020 to 2025
$7.2M
Intramural NIH HHS ZIA BC011008
6 · The paper itself

Abstract

The

Indexed as

Genes, Tumor SuppressorAdenineCarrier ProteinsCD79 AntigensCell Line, TumorDrug Resistance, NeoplasmEndoplasmic ReticulumHEK293 CellsHumansIntracellular Signaling Peptides and ProteinsLymphoma, Large B-Cell, DiffuseMutagenesis, Site-DirectedMyeloid Differentiation Factor 88NF-kappa BPiperidinesProteolysisAdenineCarrier ProteinsCD79 AntigensCD79B protein, humanibrutinibIntracellular Signaling Peptides and ProteinsKLHL14 protein, humanMYD88 protein, humanMyeloid Differentiation Factor 88NF-kappa BPiperidinesPyrazolesPyrimidinesReceptors, Antigen, B-CellUbiquitin-Protein Ligase ComplexesB cell receptorDLBCLKLHL14NF-κB

Identifiers

PMID32127472
PMCPMC7084139
OpenAlexW3009381637

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.