Evidence map›Paper›PMID 32127460›Full record

ArticlemBio2020

Modulation of Monocyte-Driven Myositis in Alphavirus Infection Reveals a Role for CX

Ali Zaid, Kothila Tharmarajah, Helen Mostafavi, Joseph R Freitas, Kuo-Ching Sheng, Suan-Sin Foo, Weiqiang Chen, Jelena Vider, Xiang Liu, Nicholas P West and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.9field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 2 countries.

Ali ZaidMenzies Health Institute Queensland, Griffith University, Southport, Queensland, Australia a.zaid@griffith.edu.au s.mahalingam@griffith.edu.au.ORCID 0000-0002-2528-2783
Kothila TharmarajahMenzies Health Institute Queensland, Griffith University, Southport, Queensland, Australia.
Helen MostafaviMenzies Health Institute Queensland, Griffith University, Southport, Queensland, Australia.
Joseph R FreitasMenzies Health Institute Queensland, Griffith University, Southport, Queensland, Australia.
Kuo-Ching ShengInstitute for Glycomics, Griffith University, Southport, Queensland, Australia.
Suan-Sin FooInstitute for Glycomics, Griffith University, Southport, Queensland, Australia.
Weiqiang ChenInstitute for Glycomics, Griffith University, Southport, Queensland, Australia.
Jelena ViderMenzies Health Institute Queensland, Griffith University, Southport, Queensland, Australia.
Xiang LiuMenzies Health Institute Queensland, Griffith University, Southport, Queensland, Australia.
Nicholas P WestMenzies Health Institute Queensland, Griffith University, Southport, Queensland, Australia.
Lara J HerreroInstitute for Glycomics, Griffith University, Southport, Queensland, Australia.ORCID 0000-0002-5661-9828
Adam TaylorMenzies Health Institute Queensland, Griffith University, Southport, Queensland, Australia.
Laura K MackayThe Doherty Institute for Infection & Immunity, Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria, Australia.
Daniel R GettsThe Discipline of Pathology, School of Medical Sciences, Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia.
Nicholas J C King *The Discipline of Pathology, School of Medical Sciences, Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia.
Suresh Mahalingam *Menzies Health Institute Queensland, Griffith University, Southport, Queensland, Australia a.zaid@griffith.edu.au s.mahalingam@griffith.edu.au.ORCID 0000-0003-3141-8410
Griffith University · AUAustralian Research Council · AUNorthwestern University · USThe University of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Arthritogenic alphaviruses such as Ross River and Chikungunya viruses cause debilitating muscle and joint pain and pose significant challenges in the light of recent outbreaks. How host immune responses are orchestrated after alphaviral infections and lead to musculoskeletal inflammation remains poorly understood. Here, we show that myositis induced by Ross River virus (RRV) infection is driven by CD11b

Indexed as

Wound HealingAlphavirus InfectionsAnimalsBiomarkersBiopsyCX3C Chemokine Receptor 1Disease Models, AnimalGene Expression ProfilingImmunomodulationImmunophenotypingMacrophagesMiceMice, TransgenicMonocytesMyositisBiomarkersCX3C Chemokine Receptor 1inflammationmacrophagesmicroparticlesmyositisRoss River virustissue repairviral infection

Identifiers

PMID32127460
PMCPMC7064784
OpenAlexW3007953393

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.