Evidence map›Paper›PMID 32127458›Full record

ArticlemBio2020

Peptidoglycan Hydrolases RipA and Ami1 Are Critical for Replication and Persistence of Mycobacterium tuberculosis in the Host.

Claire Healy, Alexandre Gouzy, Sabine Ehrt

Open access · goldAbstract read
In one paragraph

Article in mBio, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
0.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 51 citations in OpenAlex.

  1. Cell wall remodeling-dependent morphotype switch inProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Non-canonical peptidoglycan cross-linking is essential forbioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Article
  6. Review
  7. The Ubiquitination ofBiology · 2025
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. The progress ofFrontiers in medicine · 2024
    Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. FtsEX-independent control of RipA-mediated cell separation inProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Claire HealyDepartment of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, USA.
Alexandre GouzyDepartment of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, USA.
Sabine EhrtDepartment of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, USA sae2004@med.cornell.edu.ORCID 0000-0002-7951-2310
Cornell University · US

Funding

Viable but Nonculturable MtbU19AI111143 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI GLICKMAN, MICHAEL S, RHEE, KYU Y · 2014 to 2020
$48.6M
Conditional Expression of Mycobacterial GenesR01AI063446 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI EHRT, SABINE · 2006 to 2022
$7.2M
NIAID NIH HHS R01 AI063446NIAID NIH HHS U19 AI111143
6 · The paper itself

Abstract

Synthesis and cleavage of the cell wall polymer peptidoglycan (PG) are carefully orchestrated processes and are essential for the growth and survival of bacteria. Yet, the function and importance of many enzymes that act on PG in

Indexed as

Drug Resistance, BacterialHost-Pathogen InteractionsAnimalsAntitubercular AgentsBacterial ProteinsCell WallDisease Models, AnimalGenome, BacterialGenomicsMiceMutationMycobacterium tuberculosisN-Acetylmuramoyl-L-alanine AmidaseSynthetic Lethal MutationsTuberculosisAntitubercular AgentsBacterial ProteinsN-Acetylmuramoyl-L-alanine Amidasecell divisionpathogenesistuberculosis

Identifiers

PMID32127458
PMCPMC7064781
OpenAlexW3007882709

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.