Evidence map›Paper›PMID 32127453›Full record

ArticlemBio2020

Repurposed Drugs That Block the Gonococcus-Complement Receptor 3 Interaction Can Prevent and Cure Gonococcal Infection of Primary Human Cervical Epithelial Cells.

Jessica Poole, Christopher J Day, Thomas Haselhorst, Freda E-C Jen, Victor J Torres, Jennifer L Edwards, Michael P Jennings

Open access · goldAbstract read
In one paragraph

Article in mBio, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. PotentmSphere · 2022
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Sexually TransmittedMedicines (Basel, Switzerland) · 2021
    Review
  12. Anti-Virulence Therapeutic Approaches forAntibiotics (Basel, Switzerland) · 2021
    Review
  13. Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Jessica Poole *Institute for Glycomics, Griffith University, Southport, Queensland, Australia.
Christopher J Day *Institute for Glycomics, Griffith University, Southport, Queensland, Australia.
Thomas HaselhorstInstitute for Glycomics, Griffith University, Southport, Queensland, Australia.
Freda E-C JenInstitute for Glycomics, Griffith University, Southport, Queensland, Australia.
Victor J TorresDepartment of Microbiology, New York University School of Medicine, New York, New York, USA.
Jennifer L EdwardsThe Center for Microbial Pathogenesis, The Abigail Wexner Research Institute at Nationwide Children's Hospital and The Department of Pediatrics, The Ohio State University, Columbus, Ohio, USA Jennifer.Edwards@nationwidechildrens.org m.jennings@griffith.edu.au.
Michael P JenningsInstitute for Glycomics, Griffith University, Southport, Queensland, Australia Jennifer.Edwards@nationwidechildrens.org m.jennings@griffith.edu.au.
Griffith University · AUNew York University · USThe Ohio State University · US

Funding

Mechanistic Studies Of The Staphylococcus aureus LukAB CytotoxinR01AI099394 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Victor J. Torres · 2013 to 2026
$6.1M
Novel carbohydrate binding functions of the CR3 I-domain modulate gonococcal-cervical cell interactionsR01AI134848 · NIAID · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI EDWARDS, JENNIFER L, JENNINGS, MICHAEL PAUL · 2018 to 2022
$2.2M
NIAID NIH HHS R01 AI099394NIAID NIH HHS R01 AI134848
6 · The paper itself

Abstract

In the absence of a vaccine, multidrug-resistant

Indexed as

Drug RepositioningBacterial AdhesionCarbamazepineCells, CulturedCervix UteriDrug Resistance, Multiple, BacterialEpithelial CellsFemaleGalactoseHumansMethyldopaNeisseria gonorrhoeaeReceptors, ComplementSmall Molecule LibrariesCarbamazepineGalactoseMethyldopaReceptors, ComplementSmall Molecule LibrariesadherenceCD11b I-domaincomplement receptor 3CR3glycosylationgonococcal cervicitisgonococciMac-1multidrug resistanceNeisseria gonorrhoeaepilinrepurposed drug

Identifiers

PMID32127453
PMCPMC7064771
OpenAlexW3008262055

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.