ArticlemBio2020
Emergence of a Plasmid-Encoded Resistance-Nodulation-Division Efflux Pump Conferring Resistance to Multiple Drugs, Including Tigecycline, in Klebsiella pneumoniae.
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Article in mBio, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 142 papers, 1 of them a synthesis that pooled it.
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142citing papers in PubMed, 1 pooled it
11.6field-weighted citation impact, top 1% of its field
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Who cites it
142 citing papers in PubMed, 1 synthesis or guideline pooled it, 286 citations in OpenAlex.
- Global trends in carbapenem-resistant gram-negative bacteria research (2020-2025): a bibliometric analysis and systematic review.Frontiers in cellular and infection microbiology · 2025Pooled it
- Emergence ofVirulence · 2026Article
- Tetracyclines, a timely resurgence or doomed to fail again?Journal of medical microbiology · 2026Review
- Convergence of Plasmid-Mediated tmexCD-toprJ With Critical Resistance Genes Fuels Spread of Multidrug Resistant Bacteria.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Occurrence and Distribution of Environmental Pseudomonas aeruginosa From Hospitals in Bangladesh Reveals Diverse Strain Families, Multidrug Resistance, and Biofilm Formation.Environmental microbiology reports · 2026Article
- Genomic Evidence for Mobile-Element-Associated Resistance: Predicted MOBH-Family Relaxase Sharing and Adjacent ICE-Cassette Architectures in theMicroorganisms · 2026Article
- Co-occurrence of the tigecycline resistance gene clusterMicrobiology spectrum · 2026Article
- Genomic characterization of the multidrug-resistant IncP-2 plasmid pPAMS in a clinical isolate Pseudomonas aeruginosa.BMC microbiology · 2026Article
- Klebsiella pneumoniae in the global AMR: resistance mechanisms and genomic adaptation.World journal of microbiology & biotechnology · 2026Review
- A rapidly personalized in-hospital bloodstream infection prediction model: a multicenter retrospective study.BMC infectious diseases · 2026Article
- Emergence of Tigecycline-Resistant Pseudomonas aeruginosa Harbouring tmexC6D6-toprJ1b From Hospital Sewage in Japan.Environmental microbiology reports · 2026Article
- Characterization of tmexCD-toprJ-positive Klebsiella spp. from pediatric patients in a Chinese hospital.BMC microbiology · 2026Article
- A comprehensive analysis of the kinetics of infection of lytic bacteriophages specific to the ESKAPE and critical pathogens.World journal of microbiology & biotechnology · 2026Review
- Phylogenetic diversification and fitness trade-offs of TetA variants in mediating eravacycline resistance inAntimicrobial agents and chemotherapy · 2026Article
- Whole-Genome Insights Into Tigecycline-ResistantTransboundary and emerging diseases · 2026Article
- A One Health Perspective on the Plasmid Backbone Preference and Evolutionary Adaptation ofInfection and drug resistance · 2026Article
- Genetic and virulence analysis of carbapenem-resistant Pseudomonas aeruginosa in farm animals in Shandong province, China: implications for human health.BMC microbiology · 2025Article
- New resistance threat in difficult-to-treat resistanceEmerging microbes & infections · 2025Article
- Transfer and Fitness of ISMicroorganisms · 2025Article
- Assembly and inhibition of transferable TMexCD1-TOprJ1 efflux pump.Nature communications · 2025Article
82 more citing papers are in PubMed but not listed here.
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Authors and funding
17 authors at 7 institutions in 4 countries.
Luchao Lv *College of Veterinary Medicine, National Risk Assessment Laboratory for Antimicrobial Resistance of Microorganisms in Animals, Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, South China Agricultural University, Guangzhou, China.
Miao Wan *College of Veterinary Medicine, National Risk Assessment Laboratory for Antimicrobial Resistance of Microorganisms in Animals, Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, South China Agricultural University, Guangzhou, China.
Chengzhen Wang *College of Veterinary Medicine, National Risk Assessment Laboratory for Antimicrobial Resistance of Microorganisms in Animals, Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, South China Agricultural University, Guangzhou, China.
Xun Gao *College of Veterinary Medicine, National Risk Assessment Laboratory for Antimicrobial Resistance of Microorganisms in Animals, Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, South China Agricultural University, Guangzhou, China.
Qiwen Yang *Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
Sally R PartridgeCentre for Infectious Diseases and Microbiology, The Westmead Institute for Medical Research, The University of Sydney, Westmead Hospital, Sydney, Australia.ORCID 0000-0002-0666-8330
Yang WangBeijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Zhiyong ZongCenter of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China.
Yohei DoiDepartments of Microbiology and Infectious Diseases, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.
Jianzhong ShenBeijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Peiyao JiaDepartment of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
Qianhua SongCollege of Veterinary Medicine, National Risk Assessment Laboratory for Antimicrobial Resistance of Microorganisms in Animals, Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, South China Agricultural University, Guangzhou, China.
Qianhui ZhangCollege of Veterinary Medicine, National Risk Assessment Laboratory for Antimicrobial Resistance of Microorganisms in Animals, Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, South China Agricultural University, Guangzhou, China.
Jun YangCollege of Veterinary Medicine, National Risk Assessment Laboratory for Antimicrobial Resistance of Microorganisms in Animals, Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, South China Agricultural University, Guangzhou, China.
Xianhui HuangCollege of Veterinary Medicine, National Risk Assessment Laboratory for Antimicrobial Resistance of Microorganisms in Animals, Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, South China Agricultural University, Guangzhou, China.
Minggui WangInstitute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China.
Jian-Hua LiuCollege of Veterinary Medicine, National Risk Assessment Laboratory for Antimicrobial Resistance of Microorganisms in Animals, Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, South China Agricultural University, Guangzhou, China jhliu@scau.edu.cn.ORCID 0000-0002-3930-7857
South China Agricultural University · CNChina Agricultural University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNFudan University · CNFujita Health University · JPSichuan University · CNThe University of Sydney · AU
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transporters belonging to the chromosomally encoded resistance-nodulation-division (RND) superfamily mediate multidrug resistance in Gram-negative bacteria. However, the cotransfer of large gene clusters encoding RND-type pumps from the chromosome to a plasmid appears infrequent, and no plasmid-mediated RND efflux pump gene cluster has yet been found to confer resistance to tigecycline. Here, we identified a novel RND efflux pump gene cluster, designated
Indexed as
Drug Resistance, Multiple, BacterialAnimalsAnti-Bacterial AgentsEscherichia coliFemaleKlebsiella InfectionsKlebsiella pneumoniaeMembrane Transport ProteinsMiceMicrobial Sensitivity TestsMultigene FamilyPlasmidsTigecyclineAnti-Bacterial AgentsMembrane Transport ProteinsTigecyclineantimicrobial agentsefflux pumpsEnterobacteriaceaemechanisms of resistancemultidrug resistanceplasmid-mediated resistance
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.