Evidence map›Paper›PMID 32127446›Full record

ArticlemBio2020

Host Mucin Is Exploited by Pseudomonas aeruginosa To Provide Monosaccharides Required for a Successful Infection.

Casandra L Hoffman, Jonathan Lalsiamthara, Alejandro Aballay

Open access · goldAbstract read
In one paragraph

Article in mBio, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 57 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Newly developed evaluation for intestinal permeability usingJournal of clinical biochemistry and nutrition · 2025
    Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Understanding the factors regulating host-microbiome interactions usingPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024
    Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Casandra L HoffmanMolecular Microbiology and Immunology Department, Oregon Health and Sciences University, Portland, Oregon, USA.
Jonathan LalsiamtharaMolecular Microbiology and Immunology Department, Oregon Health and Sciences University, Portland, Oregon, USA.
Alejandro AballayMolecular Microbiology and Immunology Department, Oregon Health and Sciences University, Portland, Oregon, USA aballay@ohsu.edu.
Oregon Health & Science University · US

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
INTERACTIONS AT THE MICROBE/HOST INTERFACET32AI007472 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI LANDFEAR, SCOTT M · 1995 to 2019
$6.7M
Multidisciplinary Research Training in Pulmonary MedicineT32HL083808 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI LEWINSOHN, DAVID M., SLATORE, CHRISTOPHER G. · 2008 to 2025
$5.3M
Genetic analysis of innate immunity using C. elegansR01GM070977 · NIGMS · DUKE UNIVERSITY · PI ABALLAY, ALEJANDRO · 2004 to 2016
$4.2M
Genetic analysis of innate immunity using C. elegansR37GM070977 · NIGMS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Alejandro Aballay · 2017 to 2026
$3.8M
NHLBI NIH HHS T32 HL083808NIAID NIH HHS T32 AI007472NIGMS NIH HHS R01 GM070977NIGMS NIH HHS R37 GM070977NIH HHS P40 OD010440
6 · The paper itself

Abstract

One of the primary functions of the mucosal barrier, found lining epithelial cells, is to serve as a first-line of defense against microbial pathogens. The major structural components of mucus are heavily glycosylated proteins called mucins. Mucins are key components of the innate immune system as they aid in the clearance of pathogens and can decrease pathogen virulence. It has also been recently reported that individual mucins and derived glycans can attenuate the virulence of the human pathogen

Indexed as

Host-Pathogen InteractionsA549 CellsAnimalsBacterial AdhesionCaenorhabditis elegansEpithelial CellsHumansMonosaccharidesMucin-1MucinsPseudomonas aeruginosaVirulenceMonosaccharidesMUC1 protein, humanMucin-1Mucinsbacterial colonizationCaenorhabditis eleganshost-pathogen interactionsinfectioninnate immunitylung cellsmuc1mucinmul-1Pseudomonas aeruginosa

Identifiers

PMID32127446
PMCPMC7064748
OpenAlexW3008788221

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.