Evidence map›Paper›PMID 32127397›Full record

ArticleDisease models & mechanisms2020

Leptin and fractalkine: novel subcutaneous cytokines in burn injury.

Dominic Friston, Sini Junttila, Julia Borges Paes Lemes, Helen Laycock, Jose Vicente Torres-Perez, Elizabeth Want, Attila Gyenesei, Istvan Nagy

Open access · goldAbstract read
In one paragraph

Article in Disease models & mechanisms, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Burn Selection: How Fire Injury Shaped Human Evolution.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026
    Review
  2. Article
  3. Article
  4. Luteolin is an Effective Component ofClinical, cosmetic and investigational dermatology · 2022
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 4 countries.

Dominic FristonNociception Group, Section of Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK.
Sini JunttilaBioinformatics and Scientific Computing, Vienna Biocenter Core Facilities, Dr. Bohr-Gasse 3, 1030 Vienna, Austria.ORCID 0000-0003-3754-5584
Julia Borges Paes LemesDepartment of Structural and Functional Biology, Institute of Biology, State University of Campinas, Campinas, Carl Von Linnaeus, Sao Paulo, 13083-864, Brazil.
Helen LaycockNociception Group, Section of Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK.
Jose Vicente Torres-PerezNociception Group, Section of Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK.ORCID 0000-0001-6390-9690
Elizabeth WantDepartment of Metabolism, Digestion and Reproduction, Imperial College London, Exhibition Road, London SW7 2AZ, UK.
Attila GyeneseiBioinformatics and Scientific Computing, Vienna Biocenter Core Facilities, Dr. Bohr-Gasse 3, 1030 Vienna, Austria.
Istvan NagyNociception Group, Section of Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK i.nagy@imperial.ac.uk.ORCID 0000-0003-3475-6108
Chelsea and Westminster Hospital · GBVienna Biocenter · ATImperial College London · GBUniversidade Estadual de Campinas (UNICAMP) · BRUniversity of Debrecen · HU

Funding

National Centre for the Replacement, Refinement and Reduction of Animals in Research NC/K500409/1Wellcome Trust
6 · The paper itself

Abstract

Burn injury is a pathology underpinned by progressive and aberrant inflammation. It is a major clinical challenge to survival and quality of life. Although the complex local and disseminating pathological processes of a burn injury ultimately stem from local tissue damage, to date relatively few studies have attempted to characterise the local inflammatory mediator profile. Here, cytokine content and associated transcriptional changes were measured in rat skin for three hours immediately following induction of a scald-type (60°C, 2 min) burn injury model. Leptin (

Indexed as

AnimalsBurnsChemokine CX3CL1Gene Expression RegulationJanus KinasesLeptinMaleProtein Interaction MapsRats, Sprague-DawleySignal TransductionSkinSTAT Transcription FactorsChemokine CX3CL1Janus KinasesLeptinSTAT Transcription FactorsBurnCytokinesFractalkineLeptinMicrodialysisSkin

Identifiers

PMID32127397
PMCPMC7197715
OpenAlexW3010414222

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.