Evidence map›Paper›PMID 32127372›Full record

ArticleThe Journal of pharmacology and experimental therapeutics2020

Hepatic Transporter Alterations by Nuclear Receptor Agonist T0901317 in Sandwich-Cultured Human Hepatocytes: Proteomic Analysis and PBPK Modeling to Evaluate Drug-Drug Interaction Risk.

Katsuaki Ito, Noora Sjöstedt, Melina M Malinen, Cen Guo, Kim L R Brouwer

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pharmacology and experimental therapeutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 58% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Katsuaki ItoDivision of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (K.I., N.S., M.M.M., C.G., K.L.R.B.) and Drug Metabolism and Pharmacokinetics Research Department, Teijin Pharma Limited, Hino, Tokyo, Japan (K.I.).
Noora SjöstedtDivision of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (K.I., N.S., M.M.M., C.G., K.L.R.B.) and Drug Metabolism and Pharmacokinetics Research Department, Teijin Pharma Limited, Hino, Tokyo, Japan (K.I.).ORCID 0000-0001-6960-7757
Melina M MalinenDivision of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (K.I., N.S., M.M.M., C.G., K.L.R.B.) and Drug Metabolism and Pharmacokinetics Research Department, Teijin Pharma Limited, Hino, Tokyo, Japan (K.I.).ORCID 0000-0002-9955-5043
Cen GuoDivision of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (K.I., N.S., M.M.M., C.G., K.L.R.B.) and Drug Metabolism and Pharmacokinetics Research Department, Teijin Pharma Limited, Hino, Tokyo, Japan (K.I.).ORCID 0000-0001-6850-1045
Kim L R BrouwerDivision of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (K.I., N.S., M.M.M., C.G., K.L.R.B.) and Drug Metabolism and Pharmacokinetics Research Department, Teijin Pharma Limited, Hino, Tokyo, Japan (K.I.) kbrouwer@unc.edu.ORCID 0000-0003-1945-4929
University of North Carolina at Chapel Hill · US

Funding

Mechanisms of Altered Hepatic Transport: Impact on Drug TherapyR35GM122576 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KIM L.R. BROUWER · 2017 to 2026
$5.7M
NIGMS NIH HHS R35 GM122576
6 · The paper itself

Abstract

In vitro approaches for predicting drug-drug interactions (DDIs) caused by alterations in transporter protein regulation are not well established. However, reports of transporter regulation via nuclear receptor (NR) modulation by drugs are increasing. This study examined alterations in transporter protein levels in sandwich-cultured human hepatocytes (SCHH;

Indexed as

AdultATP Binding Cassette Transporter, Subfamily BBenzenesulfonamidesCells, CulturedDrug InteractionsFemaleFluorocarbonsHepatocytesHumansHydrocarbons, FluorinatedLiver X ReceptorsMiddle AgedModels, BiologicalOctamer Transcription Factor-1Organic Anion Transporters, Sodium-IndependentProteomicsABCB1 protein, humanATP Binding Cassette Transporter, Subfamily BBenzenesulfonamidesFluorocarbonsHydrocarbons, FluorinatedLiver X ReceptorsOctamer Transcription Factor-1Organic Anion Transporters, Sodium-IndependentPOU2F1 protein, humanSLC22A7 protein, humanSulfonamidesT0901317

Identifiers

PMID32127372
PMCPMC7180047
OpenAlexW3010106340

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.