Evidence map›Paper›PMID 32126888›Full record

ArticleJournal of biopharmaceutical statistics2020

Precise and accurate power of the rank-sum test for a continuous outcome.

Katie R Mollan, Ilana M Trumble, Sarah A Reifeis, Orlando Ferrer, Camden P Bay, Pedro L Baldoni, Michael G Hudgens

Abstract readComparative Study
In one paragraph

Article in Journal of biopharmaceutical statistics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Trial
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  9. Effect of Warming on Personality of Mosquitofish (Animals : an open access journal from MDPI · 2024
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  13. microPublication biology · 2022
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  16. Clinical Effectiveness of Monofilament Fibre Pads for Bacterial and Biofilm Removal in Pressure Injuries: A Retrospective Cohort Study.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Katie R MollanDepartment of Biostatistics and Center for AIDS Research, The University of North Carolina , Chapel Hill, North Carolina, USA.
Ilana M TrumbleDepartment of Biostatistics and Center for AIDS Research, The University of North Carolina , Chapel Hill, North Carolina, USA.
Sarah A ReifeisDepartment of Biostatistics and Center for AIDS Research, The University of North Carolina , Chapel Hill, North Carolina, USA.
Orlando FerrerDepartment of Biostatistics and Center for AIDS Research, The University of North Carolina , Chapel Hill, North Carolina, USA.
Camden P BayDepartment of Biostatistics and Center for AIDS Research, The University of North Carolina , Chapel Hill, North Carolina, USA.
Pedro L BaldoniDepartment of Biostatistics and Center for AIDS Research, The University of North Carolina , Chapel Hill, North Carolina, USA.
Michael G HudgensDepartment of Biostatistics and Center for AIDS Research, The University of North Carolina , Chapel Hill, North Carolina, USA.

Funding

Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
NIAID NIH HHS P30 AI050410
6 · The paper itself

Abstract

Accurate power calculations are essential in small studies containing expensive experimental units or high-stakes exposures. Herein, power of the Wilcoxon Mann-Whitney rank-sum test of a continuous outcome is formulated using a Monte Carlo approach and defining [Formula: see text] as a measure of effect size, where [Formula: see text] and [Formula: see text] denote random observations from two distributions hypothesized to be equal under the null. Effect size [Formula: see text] fosters productive communications because researchers understand [Formula: see text] is analogous to a fair coin toss, and [Formula: see text] near 0 or 1 represents a large effect. This approach is feasible even without background data. Simulations were conducted comparing the empirical power approach to existing approaches by Rosner & Glynn, Shieh and colleagues, Noether, and O'Brien-Castelloe. Approximations by Noether and O'Brien-Castelloe are shown to be inaccurate for small sample sizes. The Rosner & Glynn and Shieh, Jan & Randles approaches performed well in many small sample scenarios, though both are restricted to location-shift alternatives and neither approach is theoretically justified for small samples. The empirical method is recommended and available in the R package wmwpow.

Indexed as

AnimalsComputer SimulationData Interpretation, StatisticalHumansModels, StatisticalMonte Carlo MethodResearch DesignMann–Whitney testMonte Carlo simulationnon-parametricpower analysisWilcoxon rank-sum test

Identifiers

PMID32126888
PMCPMC7316590

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.