ArticleJournal of the American Academy of Child and Adolescent Psychiatry2021
Underconnectivity Between Visual and Salience Networks and Links With Sensory Abnormalities in Autism Spectrum Disorders.
Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Presymptomatic Biological, Structural, and Functional Diagnostic Biomarkers of Autism Spectrum Disorder.Journal of neurochemistry · 2025Pooled it
- Triple-Network Functional Connectivity in Adolescents With Autism Spectrum Disorder Compared to Early-Onset Psychosis.Autism research : official journal of the International Society for Autism Research · 2026Article
- Gestational PBDE concentrations and functional connectivity in adolescents: The HOME Study.International journal of hygiene and environmental health · 2026Article
- Generating Biologically Relevant Subtypes of Autism Spectrum Disorder with differential responses to Acute Oxytocin Administration in a Randomized Trial using Random Forest Models and K-means Clustering.medRxiv : the preprint server for health sciences · 2026Article
- Fetal functional connectivity prospectively associates with autistic traits in toddlerhood.NeuroImage. Clinical · 2026Article
- Salience Network in Autism: preliminary results on functional connectivity analysis in resting state.European archives of psychiatry and clinical neuroscience · 2025Article
- Disrupted Top-Down Modulation as a Mechanism of Impaired Multisensory Processing in Children with an Autism Spectrum Diagnosis.bioRxiv : the preprint server for biology · 2025Article
- Investigating Aberrant Salience in Autism Spectrum Disorder and Psychosis Risk: A Cross-Group Analysis.Early intervention in psychiatry · 2025Article
- Differential brain activation and network connectivity in social interactions presence and absence of physical contact.Communications biology · 2025Article
- Behavioral and neural interrelationships of sensory difficulties, intolerance of uncertainty, and anxiety in autistic children.Research in autism · 2025Article
- Functional connectivity between the visual and salience networks and autistic social features at school-age.Journal of neurodevelopmental disorders · 2025Article
- Alterations in functional connectivity in the salience network shared by depressive symptoms and smartphone overuse.Scientific reports · 2024Article
- The Insular Cortex: An Interface Between Sensation, Emotion and Cognition.Neuroscience bulletin · 2024Review
- Conduction Velocity, G-ratio, and Extracellular Water as Microstructural Characteristics of Autism Spectrum Disorder.bioRxiv : the preprint server for biology · 2024Article
- Higher Sensory Sensitivity is Linked to Greater Expansion Amongst Functional Connectivity Gradients.Journal of autism and developmental disorders · 2024Article
- Conduction velocity, G-ratio, and extracellular water as microstructural characteristics of autism spectrum disorder.PloS one · 2024Article
- Heterogeneity and convergence across seven neuroimaging modalities: a review of the autism spectrum disorder literature.Frontiers in psychiatry · 2024Review
- Why do children with autism spectrum disorder have abnormal visual perception?Frontiers in psychiatry · 2023Article
- Attenuated effective connectivity of large-scale brain networks in children with autism spectrum disorders.Frontiers in neuroscience · 2022Article
- Protocol of a randomized controlled trial to investigate the efficacy and neural correlates of mindfulness-based habit reversal training in children with Tourette syndrome.Frontiers in psychiatry · 2022Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveThe anterior insular cortex (AI), which is a part of the salience network, is critically involved in visual awareness, multisensory perception, and social and emotional processing, among other functions. In children and adolescents with autism spectrum disorders (ASDs), evidence has suggested aberrant functional connectivity (FC) of AI compared with typically developing peers. While recent studies have primarily focused on the functional connections between salience and social networks, much less is known about connectivity between AI and primary sensory regions, including visual areas, and how these patterns may be linked to autism symptomatology.
methodThe current investigation implemented functional magnetic resonance imaging to examine resting-state FC patterns of salience and visual networks in children and adolescents with ASDs compared with typically developing controls, and to relate them to behavioral measures.
resultsFunctional underconnectivity was found in the ASD group between left AI and bilateral visual cortices. Moreover, in an ASD subgroup with more atypical visual sensory profiles, FC was positively correlated with abnormal social motivational responsivity.
conclusionFindings of reduced FC between salience and visual networks in ASDs potentially indicate deficient selection of salient information. Moreover, in children and adolescents with ASDs who show strongly atypical visual sensory profiles, connectivity at seemingly more neurotypical levels may be paradoxically associated with greater impairment of social motivation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.