Evidence map›Paper›PMID 32126166›Full record

ArticleThe Journal of organic chemistry2020

Synthesis of Diaryl Hydroxyl Dicarboxylic Acids from Amino Acids.

Aleksi E K Eronen, Jere K Mannisto, Karina Moslova, Martin Nieger, Eeva Heliövaara, Timo Repo

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Article in The Journal of organic chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Aleksi E K EronenDepartment of Chemistry, University of Helsinki, A.I. Virtasenaukio 1, 00014 Helsinki, Finland.
Jere K MannistoDepartment of Chemistry, University of Helsinki, A.I. Virtasenaukio 1, 00014 Helsinki, Finland.
Karina MoslovaDepartment of Chemistry, University of Helsinki, A.I. Virtasenaukio 1, 00014 Helsinki, Finland.
Martin NiegerDepartment of Chemistry, University of Helsinki, A.I. Virtasenaukio 1, 00014 Helsinki, Finland.
Eeva HeliövaaraDepartment of Chemistry, University of Helsinki, A.I. Virtasenaukio 1, 00014 Helsinki, Finland.
Timo RepoDepartment of Chemistry, University of Helsinki, A.I. Virtasenaukio 1, 00014 Helsinki, Finland.ORCID 0000-0002-3116-6199

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Herein we report a unique method for preparing diaryl hydroxyl dicarboxylic acids in a diastereospecific manner. The three-component reaction occurs between amino acid, aromatic aldehyde, and primary alcohol in alkaline solutions under microwave-assisted conditions. The dicarboxylic acids are isolated as sodium salts in high yields (up to 77%) by direct precipitation from the reaction solution. The experimental results suggest that the diastereospecificity originates from a [3,3]-sigmatropic rearrangement followed by a sodium-assisted hydride transfer. As further shown, the previously unreported dicarboxylic acids are easily turned into corresponding δ-lactones.

Identifiers

PMID32126166
PMCPMC7497638

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.