ArticlePloS one2020
Optimized criteria for locomotion-based healthspan evaluation in C. elegans using the WorMotel system.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
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- Adult-restricted gene knock-down reveals candidates that affect locomotive healthspan in C. elegans.Biogerontology · 2023Article
- Long-Term Culture and Monitoring of Isolated Caenorhabditis elegans on Solid Media in Multi-Well Devices.Journal of visualized experiments : JoVE · 2022Article
- Multiview motion tracking based on a cartesian robot to monitor Caenorhabditis elegans in standard Petri dishes.Scientific reports · 2022Article
- High temporal resolution measurements of movement reveal novel early-life physiological decline in C. elegans.PloS one · 2022Article
- The Replica Set Method is a Robust, Accurate, and High-Throughput Approach for Assessing and Comparing Lifespan inFrontiers in aging · 2022Article
- Neuroprotective Effects against Glutamate-Induced HT-22 Hippocampal Cell Damage andPharmaceuticals (Basel, Switzerland) · 2021Article
- Phenotypic Screening inPharmaceuticals (Basel, Switzerland) · 2020Review
- Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Getting a grip on how we may age healthily is a central interest of biogerontological research. To this end, a number of academic teams developed platforms for life- and healthspan assessment in Caenorhabditis elegans. These are very appealing for medium- to high throughput screens, but a broader implementation is lacking due to many systems relying on custom scripts for data analysis that others struggle to adopt. Hence, user-friendly recommendations would help to translate raw data into interpretable results. The aim of this communication is to streamline the analysis of data obtained by the WorMotel, an economically and practically appealing screening platform, in order to facilitate the use of this system by interested researchers. We here detail recommendations for the stepwise conversion of raw image data into activity values and explain criteria for assessment of health in C. elegans based on locomotion. Our analysis protocol can easily be adopted by researchers, and all needed scripts and a tutorial are available in S1 and S2 Files.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.