ArticlePloS one2020
Pre-warming before general anesthesia with isoflurane delays the onset of hypothermia in rats.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- Standardizing Perioperative Heat to Improve Mouse (Mus musculus) Recovery.Journal of the American Association for Laboratory Animal Science : JAALAS · 2026Article
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- Circadian rhythms are disrupted in patients and preclinical models of Machado-Joseph disease.Brain : a journal of neurology · 2025Article
- Modified stereotactic neurosurgery techniques for rodent surgery enhance survival and reduce surgery time in a severe traumatic brain injury model.Scientific reports · 2025Article
- Evaluation of the cardiorespiratory and antinociceptive effects of the total intravenous anesthesia technique with xylazine-butorphanol-propofol compared to isoflurane in calves under experimental laparotomy.Frontiers in veterinary science · 2025Article
- An Overview of Anesthetic Procedures for Ferret (Mustela putorius furo) Preclinical Brain MRI: A Call for Standardization.Journal of the American Association for Laboratory Animal Science : JAALAS · 2025Review
- Comparison of ketamine/xylazine and isoflurane anesthesia on the establishment of mouse middle cerebral artery occlusion model.Experimental animals · 2023Article
- Evaluation of Active Warming and Surgical Draping for Perioperative Thermal Support in Laboratory Mice.Journal of the American Association for Laboratory Animal Science : JAALAS · 2022Article
- Rodent Thermoregulation: Considerations for Tail-Cuff Blood Pressure Measurements.Journal of the American Association for Laboratory Animal Science : JAALAS · 2022Article
- Short-term high-fat diet alters the mouse brain magnetic resonance imaging parameters consistently with neuroinflammation on males and metabolic rearrangements on females. A pre-clinical study with an optimized selection of linear mixed-effects models.Frontiers in neuroscience · 2022Article
- An Overview of the Implications for Perianesthesia Nurses in terms of Intraoperative Changes in Temperature and Factors Associated with Unintentional Postoperative Hypothermia.Journal of healthcare engineering · 2022Review
- Mouse Anesthesia: The Art and Science.ILAR journal · 2021Review
- Osseosurface electronics-thin, wireless, battery-free and multimodal musculoskeletal biointerfaces.Nature communications · 2021Article
- Using Waterless Alcohol-based Antiseptic for Skin Preparation and Active Thermal Support in Laboratory Rats.Journal of the American Association for Laboratory Animal Science : JAALAS · 2021Article
- Pre-warming following premedication limits hypothermia before and during anesthesia in Sprague-Dawley ratsCanadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2021Article
- Translation of Preclinical PET Imaging Findings: Challenges and Motion Correction to Overcome the Confounding Effect of Anesthetics.Frontiers in medicine · 2021Review
- Mechanomyography as a novel marker of nerve dysfunction and recovery in chronic entrapment neuropathy.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
General anesthesia causes hypothermia by impairing normal thermoregulatory mechanisms. When using inhalational anesthetic agents, Redistribution of warm blood from the core to the periphery is the primary mechanism in the development of hypothermia and begins following induction of anesthesia. Raising skin temperature before anesthesia reduces the temperature gradient between core and periphery, decreasing the transfer of heat. This prospective, crossover study (n = 17 adult male and female SD rats) compared three treatment groups: PW1% (pre-warming to increase core temperature 1% over baseline), PW40 (pre-warming to increase core temperature to 40°C) and NW (no warming). The PW1% group was completed first to ensure tolerance of pre-warming. Treatment order was then randomized and alternated after a washout period. Once target temperature was achieved, anesthesia was induced and maintained with isoflurane in oxygen without further external temperature support. Pre-warming was effective at delaying the onset of hypothermia, with a significant difference between PW1% (12.4 minutes) and PW40 (19.3 minutes, p = 0.0044 (95%CI -12 to -2.2), PW40 and NW (7.1 minutes, p < 0.0001 (95%CI 8.1 to 16.0) and PW1% and NW (p = 0.003, 95%CI 1.8 to 8.7). The rate of heat loss in the pre-warmed groups exceed that of the NW group: PW1% versus NW (p = 0.005, 95%CI 0.004 to 0.027), PW40 versus NW (p < 0.0001, 95%CI 0.014 to 0.036) and PW1% versus PW40 (p = 0.07, 95%CI -0.021 to 0.00066). Pre-warming alone confers a protective effect against hypothermia during volatile anesthesia; however, longer duration procedures would require additional heating support.
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