Evidence map›Paper›PMID 32125893›Full record

ArticleThe British journal of radiology2020

Prognostic impact of solid tumor component diameter in early-stage non-small cell lung carcinoma treated with intensity-modulated fractionated radiotherapy: a retrospective analysis impact of solid tumor component diameter in NSCLC treated with IMRT.

Tomohiro Itonaga, Ryuji Mikami, Mitsuru Okubo, Tatsuhiko Saito, Sachika Shiraishi, Shinji Sugahara, Koichi Tokuuye, Kazuhiro Saito

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The British journal of radiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Tomohiro ItonagaDepartment of Radiology, Tokyo Medical University Hospital, 6-7-1 Nishi-shinjyuku, Shinjyuku, Tokyo, Japan.ORCID http://orcid.org/0000-0002-1147-6843
Ryuji MikamiDepartment of Radiology, Tokyo Medical University Hospital, 6-7-1 Nishi-shinjyuku, Shinjyuku, Tokyo, Japan.
Mitsuru OkuboDepartment of Radiology, Tokyo Medical University Hospital, 6-7-1 Nishi-shinjyuku, Shinjyuku, Tokyo, Japan.
Tatsuhiko SaitoDepartment of Radiology, Tokyo Medical University Hospital, 6-7-1 Nishi-shinjyuku, Shinjyuku, Tokyo, Japan.
Sachika ShiraishiDepartment of Radiology, Tokyo Medical University Hospital, 6-7-1 Nishi-shinjyuku, Shinjyuku, Tokyo, Japan.
Shinji SugaharaDepartment of Radiology, Tokyo Medical University Hospital, 6-7-1 Nishi-shinjyuku, Shinjyuku, Tokyo, Japan.
Koichi TokuuyeDepartment of Radiology, Tokyo Medical University Hospital, 6-7-1 Nishi-shinjyuku, Shinjyuku, Tokyo, Japan.
Kazuhiro SaitoDepartment of Radiology, Tokyo Medical University Hospital, 6-7-1 Nishi-shinjyuku, Shinjyuku, Tokyo, Japan.
Tokyo Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the suitability of the new diameter-based subgroupings of the eighth edition Tumor Node Metastasis (TNM) classification system regarding radiotherapy treatment for early-stage non-small-cell lung cancer (NSCLC), we retrospectively re-analyzed the clinical data of patients treated with intensity-modulated radiotherapy using non-coplanar beams (ncIMRT) for Stage I NSCLC.

methodsBetween March 2011 and March 2018, 92 patients with 94 tumors who were diagnosed with Stage I NSCLC according to the seventh edition TNM classification system were enrolled and underwent ncIMRT of 75 Gy in 30 fractions. Local control (LC), progression-free survival (PFS), and overall survival (OS) were retrospectively investigated according to the T-classification subdivisions of the eighth edition and maximal solid tumor component diameter.

resultsThe median follow-up period was 32.5 months. The median maximum tumor and solid tumor component diameters were 22 mm and 18 mm, respectively. 3-year LC, PFS, and OS rates were 84.1%, 69.4%, and 85.3%, respectively. The 3-year LC rates were 91.0 and 76.8% in the groups with tumor diameter ≤2 cm and >2 cm, corresponding to the T1c and T1b subdivisions of the eighth edition, respectively (

conclusionLC rates after radiotherapy in patients with Stage I NSCLC were correlated with solid tumor component diameter. High LC rates in patients with solid tumor components <2 cm in diameter were associated with high PFS and OS rates. ADVANCES IN KNOWLEDGE: This study suggests that the eighth edition TNM classification system, which focuses on solid tumor components rather than tumor diameter, can be applied to radiotherapy.

Indexed as

AdenocarcinomaAgedAged, 80 and overCarcinoma, Non-Small-Cell LungCarcinoma, Squamous CellFemaleHumansLung NeoplasmsLymphatic MetastasisMaleMiddle AgedPrognosisRadiotherapy, Intensity-ModulatedRetrospective Studies

Identifiers

PMID32125893
PMCPMC7217577
OpenAlexW3009089060

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.