Evidence map›Paper›PMID 32125848›Full record

ArticleBiochemistry2020

Mutational and Functional Analyses of Substrate Binding and Catalysis of the

Flavia G Costa, Elizabeth D Greenhalgh, Thomas C Brunold, Jorge C Escalante-Semerena

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Flavia G CostaDepartment of Microbiology, University of Georgia, Athens, Georgia 30602, United States.ORCID 0000-0001-7058-6009
Elizabeth D GreenhalghDepartment of Chemistry, University of Wisconsin, Madison, Wisconsin 53706, United States.
Thomas C BrunoldDepartment of Chemistry, University of Wisconsin, Madison, Wisconsin 53706, United States.ORCID 0000-0001-6516-598X
Jorge C Escalante-SemerenaDepartment of Microbiology, University of Georgia, Athens, Georgia 30602, United States.ORCID 0000-0001-7428-2811
University of Georgia · USUniversity of Wisconsin–Madison · US

Funding

Analysis of the Metabolic Capabilities of Prokaryotic CellsR35GM130399 · NIGMS · UNIVERSITY OF GEORGIA · PI JORGE C ESCALANTE · 2019 to 2026
$5.5M
Studies of metal-containing and metal-less EutT adenosyltransferasesF31GM122394 · NIGMS · UNIVERSITY OF GEORGIA · PI COSTA, FLAVIA GISELA · 2017 to 2020
$176k
NIGMS NIH HHS F31 GM122394NIGMS NIH HHS R35 GM130399
6 · The paper itself

Abstract

atpCo(I)rrinoid adenosyltransferases (ACATs) catalyze the transfer of the adenosyl moiety from co-substrate ATP to a corrinoid substrate. ACATs are grouped into three families, namely, CobA, PduO, and EutT. The EutT family of enzymes is further divided into two classes, depending on whether they require a divalent metal ion for activity (class I and class II). To date, a structure has not been elucidated for either class of the EutT family of ACATs. In this work, results of bioinformatics analyses revealed several conserved residues between the C-terminus of EutT homologues and the structurally characterized

Indexed as

AcyltransferasesAdenosine TriphosphateAldehyde OxidoreductasesAlkyl and Aryl TransferasesBacterial ProteinsBinding SitesCatalysisCatalytic DomainCobaltCobamidesCorrinoidsKineticsLimosilactobacillus reuteriListeria monocytogenesModels, MolecularMutationAcyltransferasesAdenosine TriphosphateAldehyde OxidoreductasesAlkyl and Aryl TransferasesBacterial ProteinsCobaltCobamidescoenzyme A-acylating propionaldehyde dehydrogenase, Lactobacillus reuteriCorrinoidsTransferases

Identifiers

PMID32125848
PMCPMC7097735
OpenAlexW3010382846

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.