Evidence map›Paper›PMID 32125619›Full record

Trial reportBrain imaging and behavior2021

The participation of basolateral amygdala in the efficacy of acupuncture with deqi treating for functional dyspepsia.

Ruirui Sun, Zhaoxuan He, Peihong Ma, Shuai Yin, Tao Yin, Xiaoyan Liu, Jin Lu, Yuzhu Qu, Tingting Zhang, Liuyang Huang and 5 more

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Brain imaging and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Review
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  7. Article
  8. Review
  9. Review
  10. Review
  11. Research on acupuncture robots based on the OptiTrack motion capture system and a robotic arm.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2025
    Article
  12. Article
  13. Objectivization study of acupunctureFrontiers in neuroscience · 2024
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Evidence-based complementary and alternative medicine : eCAM · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Ruirui Sun *Acupuncture and Tuina School, Acupuncture and Brain Research Center, The 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, 37# Shierqiao Road, Chengdu, 610075, Sichuan, China.ORCID https://orcid.org/0000-0002-6887-5968
Zhaoxuan He *Acupuncture and Tuina School, Acupuncture and Brain Research Center, The 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, 37# Shierqiao Road, Chengdu, 610075, Sichuan, China.ORCID https://orcid.org/0000-0003-0192-059X
Peihong Ma *Acupuncture and Tuina School, Acupuncture and Brain Research Center, The 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, 37# Shierqiao Road, Chengdu, 610075, Sichuan, China.ORCID https://orcid.org/0000-0002-1621-6194
Shuai YinFirst Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, Henan Province, China.ORCID https://orcid.org/0000-0002-3996-3926
Tao YinAcupuncture and Tuina School, Acupuncture and Brain Research Center, The 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, 37# Shierqiao Road, Chengdu, 610075, Sichuan, China.ORCID https://orcid.org/0000-0002-9429-7153
Xiaoyan LiuAcupuncture and Tuina School, Acupuncture and Brain Research Center, The 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, 37# Shierqiao Road, Chengdu, 610075, Sichuan, China.ORCID https://orcid.org/0000-0002-3334-7153
Jin LuAcupuncture and Tuina School, Acupuncture and Brain Research Center, The 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, 37# Shierqiao Road, Chengdu, 610075, Sichuan, China.ORCID https://orcid.org/0000-0002-2471-8143
Yuzhu QuFirst Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.ORCID https://orcid.org/0000-0002-1500-283X
Tingting ZhangAcupuncture and Tuina School, Acupuncture and Brain Research Center, The 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, 37# Shierqiao Road, Chengdu, 610075, Sichuan, China.ORCID https://orcid.org/0000-0002-1304-1149
Liuyang HuangAcupuncture and Tuina School, Acupuncture and Brain Research Center, The 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, 37# Shierqiao Road, Chengdu, 610075, Sichuan, China.ORCID https://orcid.org/0000-0003-3311-527X
Xueling SuoDepartments of Radiology, Huaxi MR Research Center (HMRRC), West China Hospital of Sichuan University, Chengdu, Sichuan, China.ORCID https://orcid.org/0000-0001-5378-0280
Du LeiDepartments of Radiology, Huaxi MR Research Center (HMRRC), West China Hospital of Sichuan University, Chengdu, Sichuan, China.ORCID https://orcid.org/0000-0002-7733-3511
Qiyong GongDepartments of Radiology, Huaxi MR Research Center (HMRRC), West China Hospital of Sichuan University, Chengdu, Sichuan, China.ORCID https://orcid.org/0000-0002-5912-4871
Fanrong LiangAcupuncture and Tuina School, Acupuncture and Brain Research Center, The 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, 37# Shierqiao Road, Chengdu, 610075, Sichuan, China. lfr@cdutcm.edu.cn.ORCID https://orcid.org/0000-0003-2210-2027
Fang ZengAcupuncture and Tuina School, Acupuncture and Brain Research Center, The 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, 37# Shierqiao Road, Chengdu, 610075, Sichuan, China. zengfang@cdutcm.edu.cn.ORCID https://orcid.org/0000-0003-3854-3003

Funding

Guangdong Province Introduction of Innovative R&D Team (CN) 2019JDTD0011National Natural Science Foundation of China NO.81473602National Outstanding Youth Science Fund Project of National Natural Science Foundation of China NO.81622052the major program of the National Natural Science Foundation of China NO.81590950the Ten Thousand Talent Program W02020595
6 · The paper itself

Abstract

Deqi is taken as an indispensable requirement to achieve acupuncture efficacy. This study aimed to explore the central influence of deqi on the efficacy of acupuncture for functional dyspepsia (FD). 70 FD patients were randomized to receive 20 sessions' acupuncture treatment with (n = 35) and without deqi (n = 35). In each group, 25 FD patients randomly selected underwent functional magnetic resonance imaging (fMRI) scans before and after treatment. After group re-division according to deqi response, changes of amygdala subregions-based resting-state functional connectivity (rsFC) were compared between the acupuncture with and without obvious deqi group. The clinical changes of the Nepean Dyspepsia Symptom Index (NDSI) measuring FD symptoms were also used to further assess the correlation with amygdala subregions rsFC in FD patients. The decrease in the NDSI scores (pre-pos) in the obvious deqi group was significantly greater than that in the acupuncture without obvious deqi group (p < 0.05). Compared to the without obvious deqi group, the obvious deqi group showed significantly decreased the left basolateral amygdala (BLA) rsFC with bilateral insular (INS), putamen and middle/posterior cingulate cortex (MCC/PCC), right pallidum and hippocampus (HIPP) after treatment. The changed NDSI scores(pre-post) of all 41 FD patients was significantly positively correlated with their Fisher's transformed z value of the left BLA rsFC with left INS (r = 0.376, FDR corrected p = 0.015), and rsFC with right HIPP (r = 0.394, FDR corrected p = 0.015). The changed NDSI scores(pre-post) of the obvious deqi group was significantly negatively correlated with their Fisher's transformed z value of the right centromedial amygdala (CMA) rsFC with left medial prefrontal cortex (mPFC) (r = -0.463, p = 0.035). The results tested the hypothesis that the advantage of deqi on efficacy is related to affecting the BLA and CMA rsFC. It suggested that deqi might influence the abnormal rsFC within the salience network (SN), and participate in the adaptive modulation of disrupted relationship between the SN and default mode network (DMN).

Indexed as

Acupuncture TherapyBasolateral Nuclear ComplexDyspepsiaAmygdalaHumansMagnetic Resonance ImagingAmygdala subregionsDeqifMRIFunctional connectivityFunctional dyspepsia

Identifiers

PMID32125619

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.