ArticleBrain imaging and behavior2021
Default mode network integrity changes contribute to cognitive deficits in subcortical vascular cognitive impairment, no dementia.
Article in Brain imaging and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 23 citations in OpenAlex.
- The impact of moxibustion on brain function in vascular dementia: a neuroimaging study involving amplitude of low-frequency fluctuations and functional connectivity.Frontiers in neurology · 2025Trial
- Effects of computerized cognitive training on functional brain networks in patients with vascular cognitive impairment and no dementia.CNS neuroscience & therapeutics · 2024Trial
- Article
- Deep Learning for Classifying and Cognitive Profiling of Subcortical Vascular Cognitive Impairment.Cyborg and bionic systems (Washington, D.C.) · 2026Article
- Analysis of brain dynamics changes in patients with cerebral small vessel disease-related cognitive impairment based on electroencephalogram microstates.European journal of medical research · 2025Article
- Cortical structural degeneration and functional network connectivity changes in patients with subcortical vascular cognitive impairment.Neuroradiology · 2025Article
- Elevated vascular endothelial growth factor a is associated with disruption of default network connectivity in older adults.Brain imaging and behavior · 2025Article
- Astrocytes Lingering at a Crossroads: Neuroprotection and Neurodegeneration in Neurocognitive Dysfunction.International journal of biological sciences · 2025Review
- Functional abnormalities of the cerebellum in vascular mild cognitive impairment.Brain imaging and behavior · 2023Article
- Multimodal magnetic resonance imaging on brain structure and function changes in vascular cognitive impairment without dementia.Frontiers in aging neuroscience · 2023Review
- Mapping cortical disease-burden at individual-level in frontotemporal dementia: implications for clinical care and pharmacological trials.Brain imaging and behavior · 2022Article
- Frequency-specific alterations in intrinsic low-frequency oscillations in newly diagnosed male patients with obstructive sleep apnea.Frontiers in neuroscience · 2022Article
- Frequency-dependent white-matter functional network changes associated with cognitive deficits in subcortical vascular cognitive impairment.NeuroImage. Clinical · 2022Article
- Progressive cortical and sub-cortical alterations in patients with anti-N-methyl-D-aspartate receptor encephalitis.Journal of neurology · 2022Article
- Amyloid-PET Levels in the Precuneus and Posterior Cingulate Cortices Are Associated with Executive Function Scores in Preclinical Alzheimer's Disease Prior to Overt Global Amyloid Positivity.Journal of Alzheimer's disease : JAD · 2022Article
- Cortical and Subcortical Grey Matter Abnormalities in White Matter Hyperintensities and Subsequent Cognitive Impairment.Neuroscience bulletin · 2021Article
- Disrupted Topological Organization in White Matter Networks in Unilateral Sudden Sensorineural Hearing Loss.Frontiers in neuroscience · 2021Article
- Abnormal Default-Mode Network Homogeneity in Patients With Mild Cognitive Impairment in Chinese Communities.Frontiers in neurology · 2020Article
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 2 countries.
Funding
Abstract
Vascular cognitive impairment, no dementia (VCIND) refers to cognitive deficits associated with underlying vascular causes that are insufficient to confirm a diagnosis of dementia. The default mode network (DMN) is a large-scale brain network of interacting brain regions involved in attention, working memory and executive function. The role of DMN white matter integrity in cognitive deficits of VCIND patients is unclear. Using diffusion tensor imaging (DTI), this study was carried out to investigate white matter microstructural changes in the DMN in VCIND patients and their contributions to cognitive deficits. Thirty-one patients with subcortical VCIND and twenty-two healthy elderly subjects were recruited. All patients underwent neuropsychological assessments and DTI examination. Voxel-based analyses were performed to extract fractional anisotropy (FA) and mean diffusivity (MD) measures in the DMN. Compared with the healthy elderly subjects, patients diagnosed with subcortical VCIND presented with abnormal white matter integrity in several key hubs of the DMN. The severity of damage in the white matter microstructure in the DMN significantly correlated with cognitive dysfunction. Mediation analyses demonstrated that DTI values could account for attention, executive and language impairments, and partly mediated global cognitive dysfunction in the subcortical VCIND patients. DMN integrity is significantly impaired in subcortical VCIND patients. The disrupted DMN connectivity could explain the attention, language and executive dysfunction, which indicates that the white matter integrity of the DMN may be a neuroimaging marker for VCIND.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.