Evidence map›Paper›PMID 32125575›Full record

ArticleJournal of medical ultrasonics (2001)2020

Superb microvascular imaging compared with contrast-enhanced ultrasound to assess microvessels in thyroid nodules.

Zhao Yongfeng, Zhou Ping, Peng Hong, Liu Wengang, Zhang Yan

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Journal of medical ultrasonics (2001), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Pooled it
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  8. Ultrasound microflow patterns help in distinguishing malignant from benign thyroid nodules.Cancer imaging : the official publication of the International Cancer Imaging Society · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Zhao YongfengDepartment of Ultrasound, The Third Xiangya Hospital, Central South University, No. 138 Tongzipo Road, Yuelu District, Changsha, 410013, Hunan, China.
Zhou PingDepartment of Ultrasound, The Third Xiangya Hospital, Central South University, No. 138 Tongzipo Road, Yuelu District, Changsha, 410013, Hunan, China. zhouping1000@hotmail.com.ORCID http://orcid.org/0000-0003-1121-7339
Peng HongDepartment of Ultrasound, The Third Xiangya Hospital, Central South University, No. 138 Tongzipo Road, Yuelu District, Changsha, 410013, Hunan, China.
Liu WengangDepartment of Ultrasound, The Third Xiangya Hospital, Central South University, No. 138 Tongzipo Road, Yuelu District, Changsha, 410013, Hunan, China.
Zhang YanDepartment of Ultrasound, The Third Xiangya Hospital, Central South University, No. 138 Tongzipo Road, Yuelu District, Changsha, 410013, Hunan, China.
Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeContrast-enhanced ultrasound (CEUS) and superb microvascular imaging (SMI) can detect microvessels in thyroid nodules. Here, SMI and CEUS were compared for differentiating thyroid nodules.

methodsSeventy-six patients (102 nodules) underwent SMI and CEUS. The SMI blood flow (BF) grade and CEUS enhanced intensity (EI) were recorded for the periphery and center of each nodule, and evaluated relative to pathological findings.

resultsSMI of malignant nodules showed abundant BF in the periphery but lack of BF in the center, while CEUS showed hypoenhancement in the center and periphery. Large and small vessels had greater saliency on SMI-BF grade and CEUS-EI, respectively. Analysis of SMI-BF as diagnostic of thyroid carcinoma specifically at the nodule periphery indicated rates of 82.2%, 79.3%, and 81.3% for sensitivity, specificity, and accuracy, respectively. The corresponding rates for CEUS hypoenhancement were 80.8%, 86.2%, and 82.3%, respectively. Thus, SMI and CEUS rates were similar.

conclusionSMI-BF grade was more affected by vessels of larger inner diameter, while CEUS-EI was more affected by vessels of smaller inner diameter. SMI alone is sufficient for evaluation of blood flow in thyroid nodules, and the diagnostic value of SMI-BF of the periphery is comparable to CEUS hypoenhancement to differentiate thyroid cancer.

Indexed as

Contrast MediaPhospholipidsSulfur HexafluorideAdultDiagnosis, DifferentialFemaleHumansImage EnhancementMaleMicrovesselsMiddle AgedProspective StudiesSensitivity and SpecificityThyroid GlandThyroid NeoplasmsThyroid Nodulecontrast agent BR1Contrast MediaPhospholipidsSulfur HexafluorideContrast-enhanced ultrasoundMicrovessel densitySuperb microvascular imagingThyroidThyroid cancer

Identifiers

PMID32125575
OpenAlexW3009798552

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.