Evidence map›Paper›PMID 32125561›Full record

ArticleNeurochemical research2020

Treadmill Exercise Attenuates Aβ-Induced Mitochondrial Dysfunction and Enhances Mitophagy Activity in APP/PS1 Transgenic Mice.

Na Zhao, Qing-Wei Yan, Jie Xia, Xian-Liang Zhang, Bai-Xia Li, Ling-Yu Yin, Bo Xu

Abstract read
PubMed Publisher
In one paragraph

Article in Neurochemical research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 2 pooled it
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 55 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Review
  6. Article
  7. Regulation of autophagy-mediated pathways by diet, physical activity, and sleep in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Na ZhaoKey Laboratory of Adolescent Health Assessment and Exercise Intervention of Ministry of Education, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, China.
Qing-Wei YanSchool of Physical Education, Xi Zang Minzu University, Xianyang, China.
Jie XiaKey Laboratory of Adolescent Health Assessment and Exercise Intervention of Ministry of Education, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, China.
Xian-Liang ZhangThe School of Physical Education of Shandong University, Jinan, China.
Bai-Xia LiKey Laboratory of Adolescent Health Assessment and Exercise Intervention of Ministry of Education, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, China.
Ling-Yu YinKey Laboratory of Adolescent Health Assessment and Exercise Intervention of Ministry of Education, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, China.
Bo XuKey Laboratory of Adolescent Health Assessment and Exercise Intervention of Ministry of Education, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, China. bxu@tyxx.ecnu.edu.cn.
East China Normal University · CNShandong University · CNXizang Minzu University · CN

Funding

Achievements of Major Project Cultivation Program of Xizang Minzu University 19MDZ02National Natural Science Foundation of China 31571225Postdoctoral Science Foundation of Jiangsu Province 2017M612244
6 · The paper itself

Abstract

Mitochondrial dysfunction is a hallmark of Alzheimer's disease (AD), which may be related to mitophagy failure. Previous reports suggest that treadmill exercise protects against mitochondrial dysfunction in AD. However, few studies have investigated the relationship between mitophagy and mitochondrial adaptation caused by treadmill exercise in AD. The current study aimed to investigate whether exercise-ameliorated AD is associated with changes in mitophagy activity. Both Wild-type and APP/PS1 transgenic mice were divided into sedentary (WTC and ADC) and exercise (WTE and ADE) groups (n = 9 for each group). WTE and ADE mice were subjected to treadmill exercise for 12 weeks, followed by evaluating the effect of treadmill exercise on learning and memory ability, Aβ plaques, mitochondrial Aβ peptide level, synaptic activity and mitochondrial function. Meanwhile, mitophagy-related proteins PINK1, Parkin, LC3II and P62 were measured in the hippocampal mitochondrial fractions. The results indicated that exercise not only restored learning and memory ability, but also reduced Aβ plaque area, mitochondrial Aβ peptide level, and increased levels of synaptic markers SYN and GAP43, as well as reversed mitochondrial dysfunction (defective mitochondrial ultrastructure, decreased PGC-1α, TFAM and ATP levels) in APP/PS1 transgenic mice. Moreover, exercise increased mitophagy activity as evidenced by a significant decrease in levels of P62 and PINK1 as well as an increase in levels of LC3II and Parkin in ADE mice. These findings suggest that treadmill exercise can enhance mitophagy activity in the hippocampus, which is efficient in ameliorating pathological phenotypes of APP/PS1 transgenic mice.

Indexed as

Amyloid beta-Protein PrecursorPresenilin-1Amyloid beta-PeptidesAnimalsExercise TestMaleMaze LearningMiceMice, Inbred C57BLMice, TransgenicMitochondriaMitophagyPhysical Conditioning, AnimalAmyloid beta-PeptidesAmyloid beta-Protein PrecursorPresenilin-1Alzheimer’s diseaseMitochondrial dysfunctionMitophagyTreadmill exerciseβ-Amyloid

Identifiers

PMID32125561
OpenAlexW3010103308

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.