ArticleEuropean radiology2020
Iodine overlays to improve differentiation between peritoneal carcinomatosis and benign peritoneal lesions.
Article in European radiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Spectral CT-based radiomics signature for distinguishing malignant pulmonary nodules from benign.BMC cancer · 2023Trial
- Practical applications of photon-counting CT in oncology: an organ-based pictorial review.Insights into imaging · 2026Article
- Spectral CT in patients with colorectal cancer: quantitative contrast lesional assessment of mucinous and non-mucinous peritoneal metastases using virtual monoenergetic imaging.Abdominal radiology (New York) · 2026Article
- Spectral CT imaging in colorectal cancer: current applications, limitations, and future perspectives.Insights into imaging · 2026Review
- The Applications of Spectral CT in Interventional Radiology: Innovations in Diagnosis and Intra-procedural Guidance.Cardiovascular and interventional radiology · 2026Review
- Improved detection and quantification of peritoneal metastases using delayed contrast-enhanced dual-energy CT scans.European radiology experimental · 2025Article
- Spectral CT imaging for assessment of metastases in melanoma patients: multi-reader evaluation.Cancer imaging : the official publication of the International Cancer Imaging Society · 2025Article
- Imaging in malignant peritoneal neoplasms.Abdominal radiology (New York) · 2025Review
- Material density dual-energy CT images: value added in early diagnosis of peritoneal carcinomatosis : Original research.Abdominal radiology (New York) · 2024Article
- Three Dimensional Printing as a Tool For Anatomical Training in Lung Surgery.Medical science educator · 2023Article
- Advances in the management of peritoneal malignancies.Nature reviews. Clinical oncology · 2022Review
- Spectral CT in peritoneal carcinomatosis from ovarian cancer: a tool for differential diagnosis of small nodules?European radiology experimental · 2022Article
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12 authors.
Funding
Abstract
objectivesPeritoneal carcinomatosis (PC) is a prognostically relevant metastatic disease which may be difficult to depict in postoperative patients, particularly in early stages. This study aimed to determine whether PC could be diagnosed more accurately when using a combination of spectral detector CT (SDCT)-derived conventional images (CI) and iodine overlay images (IO) compared with CI only.
methodsThirty patients with PC and 30 patients with benign peritoneal alterations (BPA) who underwent portal-venous abdominal SDCT were included. Four radiologists determined the presence/absence of PC for each patient and assessed lesion conspicuity, diagnostic certainty, and image quality using 5-point Likert scales. Subjective assessment was conducted in two sessions comprising solely CI and CI/IO between which a latency of 6 weeks was set. Iodine uptake and HU attenuation were determined ROI-based to analyze quantitative differentiation of PC/BPA.
resultsSpecificity for PC was significantly higher when using CI/IO compared with using CI only (0.86 vs. 0.78, p ≤ 0.05), while sensitivity was comparable (0.79 vs. 0.81, p = 1). In postoperative patients, the increase in specificity was the highest (0.93 vs. 0.80, p ≤ 0.05). Lesion conspicuity was rated higher in CI/IO (4 (3-5)) compared with that in CI only (3 (3-4); p ≤ 0.05). Diagnostic certainty was comparable (both 4 (3-5); p = 0.5). CI/IO received the highest rating for overall image quality and assessability (CI/IO 5 (4-5) vs. CI 4 (4-4) vs. IO 4 (3-4); p ≤ 0.05). Area under the receiver operating characteristics curve (AUC) for quantitative differentiation between PC and BPA was higher for iodine (AUC
conclusionsCompared with CI, combination of CI/IO improves specificity in the assessment of peritoneal carcinomatosis at comparable sensitivity, particularly in postoperative patients. KEY POINTS: • Combination of iodine overlays and conventional images improves specificity when assessing patients with peritoneal carcinomatosis at comparable sensitivity. • Particularly in postsurgical patients, iodine overlays could help to avoid false-positive diagnosis of peritoneal disease. • Iodine overlays alone provided inferior image quality and assessability than conventional images, while the combination of both received the highest ratings. Iodine overlays should therefore be used in addition to and not as a substitute for conventional images.
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