ArticleCalcified tissue international2020
Long-term rates of change in musculoskeletal aging and body composition: findings from the Health, Aging and Body Composition Study.
Article in Calcified tissue international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Recent sarcopenia definitions-prevalence, agreement and mortality associations among men: Findings from population-based cohorts.Journal of cachexia, sarcopenia and muscle · 2023Pooled it
- Sex- and age-specific patterns in bone, muscle, and fat across adulthood and their relation to osteosarcopenic adiposity phenotype: a cross-sectional study.GeroScience · 2026Article
- Article
- Gaps in Population Life Course Phenotype Trajectories Underlying Major Noncommunicable Diseases: A Scoping Review.International journal of population data science · 2026Article
- Dynamic conversion and associated risk factors between mutually exclusive muscle health states in geriatric population.BMC geriatrics · 2025Article
- Ageing-Related Changes in Ultrastructural Bone Matrix Composition and Osteocyte Mechanosensitivity.Current osteoporosis reports · 2025Review
- Walking into aging: real-world mobility patterns and digital benchmarks from the InCHIANTI Study.npj aging · 2025Article
- Associations of Markers of Inflammatory Status and Adiposity with Bone Phenotype at Age 60-64 Years: Findings from the MRC National Survey of Health and Development.Calcified tissue international · 2025Article
- Circulating metabolomic biomarkers of 5-year body weight and composition change in a biracial cohort of community-dwelling older adults.GeroScience · 2025Article
- Association between atherogenic index of plasma and physical dysfunction: a cross-sectional study of middle-aged and older adults in China.Frontiers in public health · 2025Article
- Genetic and environmental determinants of bone quality: a cross-sectional analysis of the Hungarian Twin Registry.GeroScience · 2024Article
- Review
- Anthropometric indices in older adults with and without Locomotive Syndrome.BMC geriatrics · 2024Article
- Mendelian randomization study on association between grip strength and BMD in different age groups.Journal of bone and mineral metabolism · 2024Article
- Associations between Essential Amino Acid Intake and Functional Health Outcomes in Older Adults: Analysis of the National Health and Nutrition Examination Survey, 2001-2018.Current developments in nutrition · 2024Article
- Predictive value of sarcopenia components for all-cause mortality: findings from population-based cohorts.Aging clinical and experimental research · 2024Article
- Differential Effects of Endurance Exercise on Musculoskeletal and Hematopoietic Modulation in Old Mice.Aging and disease · 2024Article
- Article
- Relationships of GDF8 and 11 and Their Antagonists With Decline of Grip Strength Among Older Adults in the Baltimore Longitudinal Study of Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Exploring Muscle Health Deterioration and Its Determinants Among Community-Dwelling Older Adults.Frontiers in nutrition · 2022Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
Abstract
Musculoskeletal disorders are common among older people. Preventive strategies require understanding of age-related changes in strength, function and body composition, including how they interrelate. We have described, and examined associations between, 9-year changes in these parameters among 2917 Health, Aging and Body Composition Study participants (aged 70-79 years). Appendicular lean mass (ALM), whole body fat mass and total hip BMD were ascertained using DXA; muscle strength by grip dynamometry; and muscle function by gait speed. For each characteristic annualised percentage changes were calculated; measures of conditional change (independent of baseline) were derived and their interrelationships were examined using Pearson correlations; proportion of variance at 9-year follow-up explained by baseline level was estimated; and mean trajectories in relation to age were estimated using linear mixed models. Analyses were stratified by sex. Median [lower quartile, upper quartile] annual percentage declines were grip strength (1.5 [0.0, 2.9]), gait speed (2.0 [0.6, 3.7]), ALM (0.7 [0.1, 1.4]), fat mass (0.4 [- 1.1, 1.9]) and hip BMD (0.5 [0.0, 1.1]). Declines were linear for ALM and accelerated over time for other characteristics. Most conditional change measures were positively correlated, most strongly between ALM, fat mass and hip BMD (r > 0.28). Proportion of variation at follow-up explained by baseline was lower for grip strength and gait speed (39-52%) than other characteristics (69-86%). Strength and function declined more rapidly, and were less correlated between baseline and follow-up, than measures of body composition. Therefore, broader intervention strategies to prevent loss of strength and function in later life are required as those targeting body composition alone may be insufficient.
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Registered trials
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