Evidence map›Paper›PMID 32125452›Full record

ArticleIntensive care medicine2020

Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China.

Qiurong Ruan, Kun Yang, Wenxia Wang, Lingyu Jiang, Jianxin Song

Erratum issued 24 registry-linked trialsAbstract readLetter
In one paragraph

Article in Intensive care medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 24 registered trials, which are not on this map. Cited by 2,781 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2,781citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04323228 phase2 / phase3unknown statusnot on this map

Anti-inflammatory/Antioxidant Oral Nutrition Supplementation on the Cytokine Storm and Progression of COVID-19: A Randomized Controlled Trial

TypeinterventionalSponsorKing Saud UniversityRan2020 to 2020Enrolled40ConditionsCOVID-19ArmsOral supplement enriched in antioxidants, cellulose-containing placebo capsules
NCT04332913 unknown statusnot on this map

Efficacy and Safety of Tocilizumab in the Treatment of Patients With Respiratory Distress Syndrome and Cytokine Release Syndrome Secondary to COVID-19: a Proof of Concept Study

TypeobservationalSponsorUniversity of L'AquilaRan2020 to 2021Enrolled30ConditionsCOVID-19 Pneumonia
NCT04335071 phase2terminatednot on this map

CORON-ACT - a Multicenter, Double-blind, Randomized Controlled Phase II Trial on the Efficacy and Safety of Tocilizumab in the Treatment of Coronavirus Induced Disease (COVID-19)

TypeinterventionalSponsorInsel Gruppe AG, University Hospital BernRan2020 to 2020Enrolled5ConditionsSARS-CoV-2 InfectionArmsTocilizumab (TCZ), Placebo
NCT04337983 completednot on this map

Hemodynamic Characteristics of Patients With SARS-CoV-2: PiCCOVID Study

TypeobservationalSponsorBicetre HospitalRan2020 to 2020Enrolled60ConditionsCoronavirus, SARS-CoV-2, COVID-19, Acute Respiratory Distress SyndromeArmsTranspulmonary thermodilution, Echocardiography
NCT04340921 withdrawnnot on this map

The Role of Adaptive Immunity in COVID-19 Associated Myocardial Injury

TypeobservationalSponsorBarts & The London NHS TrustRan2020 to 2023Enrolled0ConditionsCardiovascular Disease Acute, Cardiomyopathies, COVIDArmsCOVID-19 exposure
NCT04353037 phase2terminatednot on this map

PATCH 2 & 3: (Prevention and Treatment of COVID-19 With Hydroxychloroquine) A Double-blind Placebo Controlled Randomized Trial of Hydroxychloroquine in the Prevention and Treatment of COVID-19

TypeinterventionalSponsorUnitedHealth GroupRan2020 to 2020Enrolled39ConditionsCoronavirus, Corona Virus InfectionArmsGroup 1 HCQ, Group 2 Placebo
NCT04353674 nacompletednot on this map

Novel Extracorporeal Treatment to Modulate Hyperinflammation in COVID-19 Patients

TypeinterventionalSponsorLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph'sRan2020 to 2024Enrolled12ConditionsCOVID-19, SARSArmsControl group, SLEDD with a L-MOD
NCT04356482 phase1 / phase2unknown statusnot on this map

Determination of the dose and effectiveness of convalescent plasma in severely and very severely ill patients by covid-19

TypeinterventionalSponsorInstituto de Seguridad y Servicios Sociales de los Trabajadores del EstadoRan2020 to 2020Enrolled90ConditionsCOVID-19, SARS-CoV 2, Convalescence, PlasmaArmsconvalescent plasma
NCT04358926 nacompletednot on this map

Hyperbaric Oxygen Therapy Effect in COVID-19 RCT (HBOTCOVID19)

TypeinterventionalSponsorAssaf-Harofeh Medical CenterRan2020 to 2020Enrolled30ConditionsCOVID-19, Desaturation of BloodArmsHyperbaric oxygen therapy
NCT04368156 nacompletednot on this map

A Prospective, Randomized, Controlled Study Assessing Vagus Nerve Stimulation in CoViD-19 Respiratory Symptoms (SAVIOR)

TypeinterventionalSponsorCarlos TorneroRan2020 to 2021Enrolled110ConditionsCovid-19ArmsgammaCore® (Vagus nerve stimulation)
NCT04390555 unknown statusnot on this map

COVID-19 in Hospitalised Patients With Preexisting CArdioVascular Diseases and/or Cardiac Involvement and/or Cardiovascular Risk Factors: the Global PCHF-COVICAV Registry

Typeobservational_patient_registrySponsorUniversity of ZurichRan2020 to 2021Enrolled1,500ConditionsCOVID-19, Cardiovascular Diseases, Cardiovascular Risk Factor, Heart Failure
NCT04407182 phase2completednot on this map

Safety and Efficacy of Viusid and Asbrip in Hospitalized Patients in Teodoro Maldonado Carbo Specialty's Hospital Infected and Diagnosed by SARS-Cov-2 With COVID-19

TypeinterventionalSponsorCatalysis SLRan2020 to 2020Enrolled60ConditionsCovid-19, Sars-CoV2, Diabete Mellitus, CardiopathyArmsViusid and Asbrip
NCT04457349 nacompletednot on this map

Does Therapeutic Plasma Exchange Have A Role in Resistant Cytokine Storm State Of COVID-19 Infection?

TypeinterventionalSponsorAlexandria UniversityRan2020 to 2021Enrolled10ConditionsCOVID 19ArmsTherapeutic Plasma Exchange (TPE)
NCT04461340 phase2unknown statusnot on this map

Efficacy and Safety of Sirolimus for Treating COVID-19 Infection

TypeinterventionalSponsorAlexandria UniversityRan2020 to 2020Enrolled40ConditionsCOVID 19ArmsSirolimus
NCT04492228 naunknown statusnot on this map

Randomized Open Controlled Clinical Trial to Evaluate the Effectiveness of a Eucaloric Ketogenic Nutrition in Comparison With a Standard Nutrition in Covid-19 Disease in Reducing Cytokine Storm Syndrome and ARDS

TypeinterventionalSponsorOspedale Policlinico San MartinoRan2020 to 2021Enrolled100ConditionsCovid19, Ketogenic DietingArmsKetogenic diet
NCT04513158 phase2terminatednot on this map

Convalescent Plasma in the Early Treatment of High-Risk Patients With SARS-CoV-2 (COVID-19) Infection

TypeinterventionalSponsorJoseph M. Flynn, D.O., MPHRan2020 to 2021Enrolled2ConditionsCovid19ArmsConvalescent Plasma
NCT04631536 phase3unknown statusnot on this mapstarted 2021, after this paper: background citation

Managing Endothelial Dysfunction in COVID-19 : A Randomized Controlled Trial at the Lebanese American University Medical Center- Rizk Hospital

TypeinterventionalSponsorLebanese American University Medical CenterRan2021 to 2022Enrolled42ConditionsCovid19ArmsAtorvastatin + L-arginine + Folic acid + Nicorandil + Nebivolol, Placebo
NCT04672291 phase1completednot on this mapstarted 2021, after this paper: background citation

A Phase I-Ib, Double-blinded, Randomized Repeated Dose Single Center, Safety and Immunogenicity Study of Nasal Poly-ICLC (Hiltonol®) in Healthy COVID-19 Vaccinated Adults

TypeinterventionalSponsorOncovir, Inc.Ran2021 to 2023Enrolled43ConditionsCOVID - 19ArmsPoly-ICLC (Hiltonol®) or Placebo
NCT04798716 phase1 / phase2unknown statusnot on this mapstarted 2023, after this paper: background citation

Mesenchymal Stem Cell Exosomes for the Treatment of COVID-19 Positive Patients With Acute Respiratory Distress Syndrome and/or Novel Coronavirus Pneumonia

TypeinterventionalSponsorAVEM HealthCareRan2023 to 2024Enrolled55ConditionsCovid19, Novel Coronavirus Pneumonia, Acute Respiratory Distress SyndromeArmsMSC-exosomes delivered intravenously every other day on an escalating dose: (2:4:8), MSC-exosomes delivered intravenously every other day on an escalating dose (8:4:8), MSC-exosomes delivered intravenously every other day (8:8:8)
NCT04836780 phase3unknown statusnot on this mapstarted 2021, after this paper: background citation

DEXamethasone EARLY Administration in Hospitalized Patients With Covid-19 Pneumonia and High Risk of Developing Acute Respiratory Distress Syndrome

TypeinterventionalSponsorHospital Universitario Infanta LeonorRan2021 to 2023Enrolled126ConditionsCOVID-19, Acute Respiratory Distress Syndrome, Pneumonia, ViralArmsDexamethasone
NCT04869579 phase2unknown statusnot on this mapstarted 2021, after this paper: background citation

Selenium as a Potential Treatment for Moderately-ill, Severely-ill, and Critically-ill COVID-19 Patients

TypeinterventionalSponsorCHRISTUS HealthRan2021 to 2021Enrolled100ConditionsCovid19ArmsSelenium (as Selenious Acid), Placebo
NCT05087290 completednot on this mapstarted 2021, after this paper: background citation

Longer-term Effects of COVID-19 on Blood Vessels and Blood Pressure (LOCHINVAR) Phenotyping Study

TypeobservationalSponsorUniversity of GlasgowRan2021 to 2023Enrolled150ConditionsHypertension, Covid19ArmsCases, Controls
NCT05104398 completednot on this map

Hemoperfusion With the Efferon CT Extracorporeal Adsorbers Containing Mesoporous Styrene-divinylbenzene Copolymer in Patients With Severe Covid-19

TypeobservationalSponsorEfferon JSCRan2020 to 2021Enrolled42ConditionsCOVID-19ArmsEfferon CT
NCT06940609 phase2recruitingnot on this mapstarted 2025, after this paper: background citation

Magnetic Resonance Analysis of Neural Inflammatory Factors and External Stimulation (MANIFEST)

TypeinterventionalSponsorUniversity of New MexicoRan2025 to 2029Enrolled60ConditionsLong COVID, Long COVID Syndrome, Long COVID-19 Syndrome, PASCArmsaccelerated intermittent theta burst stimulation
3 · Its place in the literature

Who cites it

2,781 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  3. COVID-19 in patients with Down syndrome: A systematic review.Immunity, inflammation and disease · 2024
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2,721 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Qiurong RuanInstitute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan, 430030, Hubei, China.ORCID http://orcid.org/0000-0002-7015-7666
Kun YangDepartment of Dermatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan, 430030, Hubei, China.ORCID http://orcid.org/0000-0001-6729-2552
Wenxia WangDepartment of Infectious Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan, 430030, Hubei, China.ORCID http://orcid.org/0000-0003-4369-6661
Lingyu JiangDepartment of Clinical Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan, 430030, Hubei, China.ORCID http://orcid.org/0000-0002-2072-0107
Jianxin SongDepartment of Infectious Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan, 430030, Hubei, China. songsingsjx@sina.com.ORCID http://orcid.org/0000-0002-4090-6670

Funding

Young Scientists Fund 81602722Young Scientists Fund 81703174
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

BetacoronavirusRisk AssessmentChinaCoronavirus InfectionsCOVID-19FemaleHumansMalePandemicsPneumonia, ViralRisk FactorsSARS-CoV-2

Identifiers

PMID32125452
PMCPMC7080116

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

and 18 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.