Evidence map›Paper›PMID 32125376›Full record

ArticleInternational journal of epidemiology2020

Statistical inference in matched case-control studies of recurrent events.

Yin Bun Cheung, Xiangmei Ma, K F Lam, Jialiang Li, Chee Fu Yung, Paul Milligan, Grant Mackenzie

Abstract read
In one paragraph

Article in International journal of epidemiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yin Bun CheungSignature Programme in Health Services & Systems Research, Duke-NUS Medical School, Singapore 169857.
Xiangmei MaCentre for Quantitative Medicine, Duke-NUS Medical School, Singapore 169856.
K F LamCentre for Quantitative Medicine, Duke-NUS Medical School, Singapore 169856.
Jialiang LiDepartment of Statistics and Applied Probability, National University of Singapore, Singapore 117546.
Chee Fu YungInfectious Disease Service, KK Women's and Children's Hospital, Singapore 229899.
Paul MilliganFaculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, WC1E 7HT, UK.
Grant MackenzieMedical Research Council Unit The Gambia at London School of Hygiene & Tropical Medicine, PO Box 273, Fajara, The Gambia.

Funding

Medical Research Council
6 · The paper itself

Abstract

backgroundThe concurrent sampling design was developed for case-control studies of recurrent events. It involves matching for time. Standard conditional logistic-regression (CLR) analysis ignores the dependence among recurrent events. Existing methods for clustered observations for CLR do not fit the complex data structure arising from the concurrent sampling design.

methodsWe propose to break the matches, apply unconditional logistic regression with adjustment for time in quintiles and residual time within each quintile, and use a robust standard error for observations clustered within persons. We conducted extensive simulation to evaluate this approach and compared it with methods based on CLR. We analysed data from a study of childhood pneumonia to illustrate the methods.

resultsThe proposed method and CLR methods gave very similar point estimates of association and showed little bias. The proposed method produced confidence intervals that achieved the target level of coverage probability, whereas the CLR methods did not, except when disease incidence was low.

conclusionsThe proposed method is suitable for the analysis of case-control studies with recurrent events.

Indexed as

Case-Control StudiesData Interpretation, StatisticalBiasChild, PreschoolCohort StudiesComputer SimulationFemaleHumansInfantInfant, NewbornLogistic ModelsMaleConcurrent designincidence density samplinglogistic regressionmatched case–control study

Identifiers

PMID32125376
PMCPMC7394959

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.