ArticleEuropean heart journal2020
The association of long-term outcome and biological sex in patients with acute heart failure from different geographic regions.
Article in European heart journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 68 citations in OpenAlex.
- Sex- and phenotype-specific prognostic implications of body mass index in acute heart failure.ESC heart failure · 2026Article
- Sex-Based Differences in Management and Outcomes of Patients Admitted or Transferred to Advanced Therapy Centers for Heart Failure.Journal of clinical medicine · 2026Article
- Ten-Year Trends in Clinical Profiles, Management, and Outcomes of De Novo Acute Heart Failure.Journal of clinical medicine · 2026Article
- Effects of Endurance and Resistance Training on Cardiovascular Outcomes and Quality of Life in Patients with Heart Failure with Reduced Ejection Fraction: A Structured Narrative Review.Journal of functional morphology and kinesiology · 2025Review
- Temporal Evolution of the Profile of Patients Hospitalized with Heart Failure (2000-2022).Clinics and practice · 2025Article
- Noninvasive Screening for Elevated LVEDP and Health Status in Outpatients at Risk for Heart Failure.JACC. Advances · 2025Article
- Race, Genetics, and Social Determinants of Health in Transthyretin Cardiac Amyloidosis: A Literature Review and Call to Action.Current cardiology reports · 2025Review
- The association of biological sex and long-term outcomes in older patients with physical restraint at the emergency department.BMC geriatrics · 2025Article
- sαKlotho protein is a useful biomarker and a promising cardioprotective agent in acute heart failure.Archives of medical science : AMS · 2025Article
- Sex differences in clinical characteristics and long-term clinical outcomes in Asian hospitalized heart failure patients.ESC heart failure · 2024Article
- Correlation of aortic root dimensions and mortality in acute heart failure: A nationwide prospective cohort study.Heliyon · 2024Article
- Sex-specific cardiac magnetic resonance pulmonary capillary wedge pressure.European heart journal open · 2024Article
- Sex-stratified genome-wide association and transcriptome-wide Mendelian randomization studies reveal drug targets of heart failure.Cell reports. Medicine · 2024Article
- Sex difference in incidence and risk factors of hospitalization for heart failure, and subsequent mortality: findings from the China PEACE million persons project.BMC public health · 2023Article
- Lagging behind the Western countries: the knowledge gaps of gender differences in heart failure in Asia.ESC heart failure · 2023Review
- Sex-Related Differences in Short-Term Prognosis in Patients with Acute Myocardial Infarction-Related Cardiogenic Shock Receiving Impella Support in Japan: From the J-PVAD Registry.Medicina (Kaunas, Lithuania) · 2023Article
- Sex Differences in Acute Heart Failure Management: Is There a Gap in Treatment Quality?Current heart failure reports · 2023Review
- Usefulness of Systemic Venous Ultrasound Protocols in the Prognosis of Heart Failure Patients: Results from a Prospective Multicentric Study.Journal of clinical medicine · 2023Article
- Investigating the causal relationships between excess adiposity and cardiometabolic health in men and women.Diabetologia · 2023Article
- Pathophysiology and Outcomes of Endothelium Function in Coronary Microvascular Diseases: A Systematic Review of Randomized Controlled Trials and Multicenter Study.Biomedicines · 2022Review
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Authors and funding
23 authors at 18 institutions in 14 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsRecent data from national registries suggest that acute heart failure (AHF) outcomes might vary in men and women, however, it is not known whether this observation is universal. The aim of this study was to evaluate the association of biological sex and 1-year all-cause mortality in patients with AHF in various regions of the world. METHODS AND
resultsWe analysed several AHF cohorts including GREAT registry (22 523 patients, mostly from Europe and Asia) and OPTIMIZE-HF (26 376 patients from the USA). Clinical characteristics and medication use at discharge were collected. Hazard ratios (HRs) for 1-year mortality according to biological sex were calculated using a Cox proportional hazards regression model with adjustment for baseline characteristics (e.g. age, comorbidities, clinical and laboratory parameters at admission, left ventricular ejection fraction). In the GREAT registry, women had a lower risk of death in the year following AHF [HR 0.86 (0.79-0.94), P < 0.001 after adjustment]. This was mostly driven by northeast Asia [n = 9135, HR 0.76 (0.67-0.87), P < 0.001], while no significant differences were seen in other countries. In the OPTIMIZE-HF registry, women also had a lower risk of 1-year death [HR 0.93 (0.89-0.97), P < 0.001]. In the GREAT registry, women were less often prescribed with a combination of angiotensin-converting enzyme inhibitors and beta-blockers at discharge (50% vs. 57%, P = 0.001).
conclusionGlobally women with AHF have a lower 1-year mortality and less evidenced-based treatment than men. Differences among countries need further investigation. Our findings merit consideration when designing future global clinical trials in AHF.
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