ArticleeLife2020
Lamina-specific AMPA receptor dynamics following visual deprivation in vivo.
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Astrocyte Modulation of Synaptic Plasticity Mediated by Activity-Dependent Sonic Hedgehog Signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Automatic detection of fluorescently labeled synapses in volumetric in vivo imaging data.bioRxiv : the preprint server for biology · 2025Article
- Stimulus-dependent synaptic plasticity underlies neuronal circuitry refinement in the mouse primary visual cortex.Cell reports · 2024Article
- Bioorthogonal chemical labeling of endogenous neurotransmitter receptors in living mouse brains.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Impairments in endogenous AMPA receptor dynamics correlates with learning deficits in Alzheimer's disease model mice.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Cross-modality supervised image restoration enables nanoscale tracking of synaptic plasticity in living mice.Nature methods · 2023Article
- Detecting Early Cognitive Decline in Alzheimer's Disease with Brain Synaptic Structural and Functional Evaluation.Biomedicines · 2023Review
- Unraveling the mysteries of dendritic spine dynamics: Five key principles shaping memory and cognition.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2023Article
- REM sleep promotes bidirectional plasticity in developing visual cortexNeurobiology of sleep and circadian rhythms · 2022Article
- Visualizing synaptic plasticity in vivo by large-scale imaging of endogenous AMPA receptors.eLife · 2021Article
- Article
- Aberrant development of excitatory circuits to inhibitory neurons in the primary visual cortex after neonatal binocular enucleation.Scientific reports · 2021Article
- Sensory input drives rapid homeostatic scaling of the axon initial segment in mouse barrel cortex.Nature communications · 2021Article
- GRIP1 regulates synaptic plasticity and learning and memory.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Regulation of AMPA receptor (AMPAR) expression is central to synaptic plasticity and brain function, but how these changes occur in vivo remains elusive. Here, we developed a method to longitudinally monitor the expression of synaptic AMPARs across multiple cortical layers in awake mice using two-photon imaging. We observed that baseline AMPAR expression in individual spines is highly dynamic with more dynamics in primary visual cortex (V1) layer 2/3 (L2/3) neurons than V1 L5 neurons. Visual deprivation through binocular enucleation induces a synapse-specific and depth-dependent change of synaptic AMPARs in V1 L2/3 neurons, wherein deep synapses are potentiated more than superficial synapses. The increase is specific to L2/3 neurons and absent on apical dendrites of L5 neurons, and is dependent on expression of the AMPAR-binding protein GRIP1. Our study demonstrates that specific neuronal connections, across cortical layers and even within individual neurons, respond uniquely to changes in sensory experience.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.