Evidence map›Paper›PMID 32125011›Full record

ArticleJournal of cutaneous pathology2020

Cutaneous microsporidiosis in an immunosuppressed patient.

Daniel A Nadelman, Ashley R Bradt, Yvonne Qvarnstrom, Cynthia S Goldsmith, Sherif R Zaki, Frank Wang, Emily H Smith, Douglas R Fullen

Open access · bronzeAbstract readCase Reports
In one paragraph

Article in Journal of cutaneous pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Daniel A NadelmanUniversity of Michigan Medical School, Ann Arbor, Michigan, USA.ORCID https://orcid.org/0000-0002-7953-6240
Ashley R BradtDepartment of Pathology, University of Michigan, Ann Arbor, Michigan, USA.
Yvonne QvarnstromCenters for Global Health, Division of Parasitic Diseases, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia.
Cynthia S GoldsmithNational Center for Emerging and Zoonotic Infectious Diseases, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia.
Sherif R ZakiNational Center for Emerging and Zoonotic Infectious Diseases, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia.
Frank WangDepartment of Dermatology, University of Michigan, Ann Arbor, Michigan, USA.
Emily H SmithDepartment of Dermatology, University of Missouri, Columbia, Missouri, USA.
Douglas R FullenDepartment of Pathology, University of Michigan, Ann Arbor, Michigan, USA.ORCID https://orcid.org/0000-0002-2524-4509
University of Michigan · USCenters for Disease Control and Prevention · USUniversity of Missouri · US

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

Microsporidia are a group of obligate intracellular parasites that naturally infect domestic and wild animals. Human microsporidiosis is an increasingly recognized multisystem opportunistic infection. The clinical manifestations are diverse with diarrhea being the most common presenting symptom. We present a 52-year-old woman with a history of amyopathic dermatomyositis complicated by interstitial lung disease managed with mycophenolate mofetil and hydroxychloroquine who presented with a 7-month history of recurrent subcutaneous nodules as well as intermittent diarrhea and chronic sinusitis. A punch biopsy showed superficial and deep lymphocytic and granulomatous dermatitis with focal necrosis. Tissue stains for microorganisms revealed oval 1 to 3 μm spores within the necrotic areas in multiple tissue stains. Additional studies at the Centers for Disease Control and Prevention confirmed cutaneous microsporidiosis. This case is one of very few confirmed examples of cutaneous microsporidiosis reported in the literature.

Indexed as

Immunocompromised HostDermatomycosesDermatomyositisEnzyme InhibitorsFemaleHumansHydroxychloroquineLung Diseases, InterstitialMicrosporidiosisMiddle AgedMycophenolic AcidEnzyme InhibitorsHydroxychloroquineMycophenolic Acidcutaneousimmunosuppressionmicrosporidiamicrosporidiosis

Identifiers

PMID32125011
PMCPMC8805087
OpenAlexW3009066516

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.